NF-κB and the immunoglobulin κ gene enhancer

Ranjan Sen

Research output: Contribution to journalArticlepeer-review

Abstract

Enhancers regulate lineage choice and the developmental timing of antigen receptor gene rearrangements. The transcription factor NF-κB has been implicated as a key component of the recombination and transcription activation potential of the immunoglobulin κ chain gene intronic enhancer. Here, I discuss the implications of the new observation that an NF-κB binding site-mutated enhancer in the correct biological context does not appear to affect κ gene expression.

Original languageEnglish (US)
Pages (from-to)1099-1102
Number of pages4
JournalJournal of Experimental Medicine
Volume200
Issue number9
DOIs
StatePublished - Nov 1 2004
Externally publishedYes

ASJC Scopus subject areas

  • Immunology

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