NF-κB and the immunoglobulin κ gene enhancer

Ranjan Sen

Research output: Contribution to journalArticle

Abstract

Enhancers regulate lineage choice and the developmental timing of antigen receptor gene rearrangements. The transcription factor NF-κB has been implicated as a key component of the recombination and transcription activation potential of the immunoglobulin κ chain gene intronic enhancer. Here, I discuss the implications of the new observation that an NF-κB binding site-mutated enhancer in the correct biological context does not appear to affect κ gene expression.

Original languageEnglish (US)
Pages (from-to)1099-1102
Number of pages4
JournalJournal of Experimental Medicine
Volume200
Issue number9
DOIs
StatePublished - Nov 1 2004
Externally publishedYes

Fingerprint

Immunoglobulin Subunits
Immunoglobulin Genes
Antigen Receptors
Gene Rearrangement
Transcriptional Activation
Genetic Recombination
Transcription Factors
Binding Sites
Gene Expression

ASJC Scopus subject areas

  • Immunology

Cite this

NF-κB and the immunoglobulin κ gene enhancer. / Sen, Ranjan.

In: Journal of Experimental Medicine, Vol. 200, No. 9, 01.11.2004, p. 1099-1102.

Research output: Contribution to journalArticle

Sen, Ranjan. / NF-κB and the immunoglobulin κ gene enhancer. In: Journal of Experimental Medicine. 2004 ; Vol. 200, No. 9. pp. 1099-1102.
@article{531a31b31f1344b9b18c36c370c5d087,
title = "NF-κB and the immunoglobulin κ gene enhancer",
abstract = "Enhancers regulate lineage choice and the developmental timing of antigen receptor gene rearrangements. The transcription factor NF-κB has been implicated as a key component of the recombination and transcription activation potential of the immunoglobulin κ chain gene intronic enhancer. Here, I discuss the implications of the new observation that an NF-κB binding site-mutated enhancer in the correct biological context does not appear to affect κ gene expression.",
author = "Ranjan Sen",
year = "2004",
month = "11",
day = "1",
doi = "10.1084/jem.20041255",
language = "English (US)",
volume = "200",
pages = "1099--1102",
journal = "Journal of Experimental Medicine",
issn = "0022-1007",
publisher = "Rockefeller University Press",
number = "9",

}

TY - JOUR

T1 - NF-κB and the immunoglobulin κ gene enhancer

AU - Sen, Ranjan

PY - 2004/11/1

Y1 - 2004/11/1

N2 - Enhancers regulate lineage choice and the developmental timing of antigen receptor gene rearrangements. The transcription factor NF-κB has been implicated as a key component of the recombination and transcription activation potential of the immunoglobulin κ chain gene intronic enhancer. Here, I discuss the implications of the new observation that an NF-κB binding site-mutated enhancer in the correct biological context does not appear to affect κ gene expression.

AB - Enhancers regulate lineage choice and the developmental timing of antigen receptor gene rearrangements. The transcription factor NF-κB has been implicated as a key component of the recombination and transcription activation potential of the immunoglobulin κ chain gene intronic enhancer. Here, I discuss the implications of the new observation that an NF-κB binding site-mutated enhancer in the correct biological context does not appear to affect κ gene expression.

UR - http://www.scopus.com/inward/record.url?scp=8644252062&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=8644252062&partnerID=8YFLogxK

U2 - 10.1084/jem.20041255

DO - 10.1084/jem.20041255

M3 - Article

C2 - 15520242

AN - SCOPUS:8644252062

VL - 200

SP - 1099

EP - 1102

JO - Journal of Experimental Medicine

JF - Journal of Experimental Medicine

SN - 0022-1007

IS - 9

ER -