NF-κB: An essential transcription factor in psoriasis

A. M. Goldminz, S. C. Au, N. Kim, A. B. Gottlieb, P. F. Lizzul

Research output: Contribution to journalReview articlepeer-review

Abstract

Nuclear factor kappa B (NF-κB) is a protein transcription factor that orchestrates inflammation and other complex biological processes. It is a key regulatory element in a variety of immune and inflammatory pathways, in cellular proliferation and differentiation and in apoptosis. Therefore NF-κB is a crucial mediator involved in the pathogenesis of psoriasis. Psoriasis, an inflammatory dermatosis, is marked by elevated levels of active, phosphorylated NF-κB. Genomic studies have also linked psoriasis with mediators in the NF-κB pathway. NF-κB has been hypothesized to connect the altered keratinocyte and immune cell behavior that characterizes the psoriatic milieu. Several anti-psoriatic therapies, including tumor necrosis factor-α blockers and glucocorticoids, reduce active NF-κB levels and related down-stream elements, and other biologics currently in development, including interleukin-17 blockers, may also target this pathway. Compounds that specifically target NF-κB signaling may be developed as novel therapeutics for chronic inflammatory disorders including psoriasis. However, chronic NF-κB inhibition could also result in immunodeficiencies. Therefore, a delicate balance must be found that maximizes therapeutic potential while limiting harmful effects, and may be achieved through several possible approaches, including localized therapy, selective inhibition of NF-κB signaling in pathologic cells, incomplete pathway inhibition or short treatment durations.

Original languageEnglish (US)
Pages (from-to)89-94
Number of pages6
JournalJournal of Dermatological Science
Volume69
Issue number2
DOIs
StatePublished - Feb 2013
Externally publishedYes

Keywords

  • Inflammation
  • Keratinocytes
  • NF-κB
  • Psoriasis
  • T-cells
  • TNF-α

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Dermatology

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