Abstract
Next-generation sequencing has enabled genome-wide molecular profiling of gastric and esophageal malignancies at single-nucleotide resolution. The resultant genomic profiles provide information about the specific oncogenic pathways that are the likely driving forces behind tumorigenesis and progression. The abundance of available genomic data has immense potential to redefine management paradigms for these difficult disease processes. The ability to capitalize on the information provided through high-throughput sequencing technologies will define cancer care in the coming decades and could shift the paradigm from current stage-based, organ-specific treatments toward tailored regimens that target the specific culprit pathways driving individual tumors.
Original language | English (US) |
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Pages (from-to) | 511-527 |
Number of pages | 17 |
Journal | Surgical Clinics of North America |
Volume | 99 |
Issue number | 3 |
DOIs | |
State | Published - Jun 2019 |
Keywords
- Gastric and esophageal cancers
- High-throughput sequencing
- Microsatellite instability
- Next-generation sequencing
ASJC Scopus subject areas
- Surgery