Next-generation Sequencing in the Management of Gastric and Esophageal Cancers

Jill C. Rubinstein, Norman G. Nicolson, Nita Ahuja

Research output: Contribution to journalReview article

Abstract

Next-generation sequencing has enabled genome-wide molecular profiling of gastric and esophageal malignancies at single-nucleotide resolution. The resultant genomic profiles provide information about the specific oncogenic pathways that are the likely driving forces behind tumorigenesis and progression. The abundance of available genomic data has immense potential to redefine management paradigms for these difficult disease processes. The ability to capitalize on the information provided through high-throughput sequencing technologies will define cancer care in the coming decades and could shift the paradigm from current stage-based, organ-specific treatments toward tailored regimens that target the specific culprit pathways driving individual tumors.

Original languageEnglish (US)
JournalSurgical Clinics of North America
DOIs
StatePublished - Jan 1 2019
Externally publishedYes

Fingerprint

Esophageal Neoplasms
Stomach Neoplasms
Neoplasms
Stomach
Carcinogenesis
Nucleotides
Genome
Technology

Keywords

  • Gastric and esophageal cancers
  • High-throughput sequencing
  • Microsatellite instability
  • Next-generation sequencing

ASJC Scopus subject areas

  • Surgery

Cite this

Next-generation Sequencing in the Management of Gastric and Esophageal Cancers. / Rubinstein, Jill C.; Nicolson, Norman G.; Ahuja, Nita.

In: Surgical Clinics of North America, 01.01.2019.

Research output: Contribution to journalReview article

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