News from the nucleolus: rRNA gene expression

Barbara Sollner-Webb, Edward B. Mougey

Research output: Contribution to journalArticle

Abstract

Although the typical, actively growing eukaryotic cell contains over 10 000 different transcripts, half of its RNA synthetic capacity is devoted to the production of a single kind of RNA. This is the pre-ribosomal RNA, which is synthesized in a special compartment of the nucleus, the nucleolus, and is the exclusive product of transcription by RNA polymerase I. In vivo and in vitro approaches have revealed the major features of rRNA gene transcription and of the subsequent processing of the primary transcript.

Original languageEnglish (US)
Pages (from-to)58-62
Number of pages5
JournalTrends in Biochemical Sciences
Volume16
Issue numberC
DOIs
StatePublished - 1991

Fingerprint

Transcription
rRNA Genes
Gene expression
RNA
RNA Polymerase I
Gene Expression
Ribosomal RNA
Eukaryotic Cells
Genes
Processing
In Vitro Techniques

ASJC Scopus subject areas

  • Biochemistry

Cite this

News from the nucleolus : rRNA gene expression. / Sollner-Webb, Barbara; Mougey, Edward B.

In: Trends in Biochemical Sciences, Vol. 16, No. C, 1991, p. 58-62.

Research output: Contribution to journalArticle

Sollner-Webb, Barbara ; Mougey, Edward B. / News from the nucleolus : rRNA gene expression. In: Trends in Biochemical Sciences. 1991 ; Vol. 16, No. C. pp. 58-62.
@article{37a1c72e333c46b98467f97ca2bb1f90,
title = "News from the nucleolus: rRNA gene expression",
abstract = "Although the typical, actively growing eukaryotic cell contains over 10 000 different transcripts, half of its RNA synthetic capacity is devoted to the production of a single kind of RNA. This is the pre-ribosomal RNA, which is synthesized in a special compartment of the nucleus, the nucleolus, and is the exclusive product of transcription by RNA polymerase I. In vivo and in vitro approaches have revealed the major features of rRNA gene transcription and of the subsequent processing of the primary transcript.",
author = "Barbara Sollner-Webb and Mougey, {Edward B.}",
year = "1991",
doi = "10.1016/0968-0004(91)90025-Q",
language = "English (US)",
volume = "16",
pages = "58--62",
journal = "Trends in Biochemical Sciences",
issn = "0376-5067",
publisher = "Elsevier Limited",
number = "C",

}

TY - JOUR

T1 - News from the nucleolus

T2 - rRNA gene expression

AU - Sollner-Webb, Barbara

AU - Mougey, Edward B.

PY - 1991

Y1 - 1991

N2 - Although the typical, actively growing eukaryotic cell contains over 10 000 different transcripts, half of its RNA synthetic capacity is devoted to the production of a single kind of RNA. This is the pre-ribosomal RNA, which is synthesized in a special compartment of the nucleus, the nucleolus, and is the exclusive product of transcription by RNA polymerase I. In vivo and in vitro approaches have revealed the major features of rRNA gene transcription and of the subsequent processing of the primary transcript.

AB - Although the typical, actively growing eukaryotic cell contains over 10 000 different transcripts, half of its RNA synthetic capacity is devoted to the production of a single kind of RNA. This is the pre-ribosomal RNA, which is synthesized in a special compartment of the nucleus, the nucleolus, and is the exclusive product of transcription by RNA polymerase I. In vivo and in vitro approaches have revealed the major features of rRNA gene transcription and of the subsequent processing of the primary transcript.

UR - http://www.scopus.com/inward/record.url?scp=0026057310&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026057310&partnerID=8YFLogxK

U2 - 10.1016/0968-0004(91)90025-Q

DO - 10.1016/0968-0004(91)90025-Q

M3 - Article

C2 - 1858134

AN - SCOPUS:0026057310

VL - 16

SP - 58

EP - 62

JO - Trends in Biochemical Sciences

JF - Trends in Biochemical Sciences

SN - 0376-5067

IS - C

ER -