TY - JOUR
T1 - News from the nucleolus
T2 - rRNA gene expression
AU - Sollner-Webb, Barbara
AU - Mougey, Edward B.
PY - 1991
Y1 - 1991
N2 - Although the typical, actively growing eukaryotic cell contains over 10 000 different transcripts, half of its RNA synthetic capacity is devoted to the production of a single kind of RNA. This is the pre-ribosomal RNA, which is synthesized in a special compartment of the nucleus, the nucleolus, and is the exclusive product of transcription by RNA polymerase I. In vivo and in vitro approaches have revealed the major features of rRNA gene transcription and of the subsequent processing of the primary transcript.
AB - Although the typical, actively growing eukaryotic cell contains over 10 000 different transcripts, half of its RNA synthetic capacity is devoted to the production of a single kind of RNA. This is the pre-ribosomal RNA, which is synthesized in a special compartment of the nucleus, the nucleolus, and is the exclusive product of transcription by RNA polymerase I. In vivo and in vitro approaches have revealed the major features of rRNA gene transcription and of the subsequent processing of the primary transcript.
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U2 - 10.1016/0968-0004(91)90025-Q
DO - 10.1016/0968-0004(91)90025-Q
M3 - Article
C2 - 1858134
AN - SCOPUS:0026057310
SN - 0968-0004
VL - 16
SP - 58
EP - 62
JO - Trends in biochemical sciences
JF - Trends in biochemical sciences
IS - C
ER -