Abstract
Lowering low-density lipoprotein cholesterol (LDL-C) is a wellestablished strategy for cardiovascular risk reduction. Inherently, the focus is on LDL’s cholesterol content rather than its particle concentration. However, a number of studies have demonstrated that measures of particles burden, such as apolipoprotein B (apoB) and LDL particle concentration (LDL-P) can be discordant with LDL-C. When discordant, they appear to more strongly predict cardiovascular events, compared with LDL-C. Triglyceride-rich lipoproteins (TRL) play a key role in generating small dense LDL particles and are now causally implicated in atherosclerosis. This book chapter reviews the most important information about TRL, apoB, and LDL-P, and discusses relevant scenarios for the clinician where discordance between lipoprotein cholesterol content and lipoprotein particle concentration measurements should be considered.
Original language | English (US) |
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Title of host publication | Cardiac Biomarkers: Case Studies and Clinical Correlations |
Publisher | Springer International Publishing |
Pages | 145-158 |
Number of pages | 14 |
ISBN (Electronic) | 9783319429823 |
ISBN (Print) | 9783319429809 |
DOIs | |
State | Published - Jan 1 2016 |
Keywords
- Apolipoprotein B
- Discordance
- Lipid markers
- Low-density lipoprotein cholesterol
- Low-density lipoprotein particle number
- Remnant lipoprotein particles cholesterol
- Triglycerides
ASJC Scopus subject areas
- General Medicine