Newborn thyroxine levels and childhood ADHD

Offie Porat Soldin, Arvind K N Nandedkar, Knoxley M. Japal, Mark Stein, Shiela Mosee, Phyllis Magrab, Shenghan Lai, Steven H. Lamm

Research output: Contribution to journalArticle

Abstract

Objectives: Normal brain development is highly dependent on adequate levels of iodine and thyroid hormone. It has been suggested that Attention Deficit Hyperactivity Disorder (ADHD) is the consequence of prenatal thyroidal endocrine disruption. The hypothesis was examined using neonatal thyroxine levels as a bio-marker of prenatal thyroid status and comparing it to subsequent development of ADHD. Design and methods: In a matched case-control study, cases were defined as children diagnosed with ADHD, while children born in the same hospital and tested on the same day served as matched controls. Conditional logistic regression analysis with unequal numbers of controls was performed. Results: The neonatal thyroxine levels were within normal limits for each of the children who were subsequently diagnosed as having ADHD, and their distribution was no different from that of their controls. Conclusions: Children diagnosed with ADHD do not demonstrate prenatal thyroidal dysfunction as reflected in the newborn thyroxine levels, therefore neonatal thyroxine levels are not a bio-marker for the subsequent development of ADHD.

Original languageEnglish (US)
Pages (from-to)131-136
Number of pages6
JournalClinical Biochemistry
Volume35
Issue number2
DOIs
StatePublished - 2002

Fingerprint

Attention Deficit Disorder with Hyperactivity
Thyroxine
Newborn Infant
Thyroid Hormones
Regression analysis
Iodine
Logistics
Brain
Case-Control Studies
Thyroid Gland
Logistic Models
Regression Analysis

Keywords

  • ADHD
  • Attention deficit hyperactivity disorder
  • Neonatal thyroxine (T)
  • Thyroid dysfunction
  • Thyroid hormone

ASJC Scopus subject areas

  • Clinical Biochemistry

Cite this

Soldin, O. P., Nandedkar, A. K. N., Japal, K. M., Stein, M., Mosee, S., Magrab, P., ... Lamm, S. H. (2002). Newborn thyroxine levels and childhood ADHD. Clinical Biochemistry, 35(2), 131-136. https://doi.org/10.1016/S0009-9120(02)00284-9

Newborn thyroxine levels and childhood ADHD. / Soldin, Offie Porat; Nandedkar, Arvind K N; Japal, Knoxley M.; Stein, Mark; Mosee, Shiela; Magrab, Phyllis; Lai, Shenghan; Lamm, Steven H.

In: Clinical Biochemistry, Vol. 35, No. 2, 2002, p. 131-136.

Research output: Contribution to journalArticle

Soldin, OP, Nandedkar, AKN, Japal, KM, Stein, M, Mosee, S, Magrab, P, Lai, S & Lamm, SH 2002, 'Newborn thyroxine levels and childhood ADHD', Clinical Biochemistry, vol. 35, no. 2, pp. 131-136. https://doi.org/10.1016/S0009-9120(02)00284-9
Soldin OP, Nandedkar AKN, Japal KM, Stein M, Mosee S, Magrab P et al. Newborn thyroxine levels and childhood ADHD. Clinical Biochemistry. 2002;35(2):131-136. https://doi.org/10.1016/S0009-9120(02)00284-9
Soldin, Offie Porat ; Nandedkar, Arvind K N ; Japal, Knoxley M. ; Stein, Mark ; Mosee, Shiela ; Magrab, Phyllis ; Lai, Shenghan ; Lamm, Steven H. / Newborn thyroxine levels and childhood ADHD. In: Clinical Biochemistry. 2002 ; Vol. 35, No. 2. pp. 131-136.
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