New synthesis of 2-aminobicyclo[2.1.1]hexane-2,5-dicarboxylic acid-I (ABHxD-I), a potent metabotropic receptor agonist

Paola Conti, Alan P. Kozikowski

Research output: Contribution to journalArticlepeer-review

Abstract

A new versatile synthesis of racemic ABHxD-I, a potent mGluR agonist, is presented. The synthesis was achieved by means of a Wolff rearrangement, which converted a 3-diazobicyclo[2.2.1]heptan-2-one into a bicyclo[2.1.1]hexane derivative. (C) 2000 Elsevier Science Ltd.

Original languageEnglish (US)
Pages (from-to)4053-4056
Number of pages4
JournalTetrahedron Letters
Volume41
Issue number21
DOIs
StatePublished - May 29 2000

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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