New roles for model genetic organisms in understanding and treating human disease: Report from the 2006 Genetics Society of America meeting

Allan Spradling, Barry Ganetsky, Phil Hieter, Mark Johnston, Maynard Olson, Terry Orr-Weaver, Janet Rossant, Alejandro Sanchez, Robert Waterston

Research output: Contribution to journalArticle

Abstract

Fundamental biological knowledge and the technology to acquire it have been immeasurably advanced by past efforts to understand and manipulate the genomes of model organisms. Has the utility of bacteria, yeast, worms, flies, mice, plants, and other models now peaked and are humans poised to become the model organism of the future? The Genetics Society of America recently convened its 2006 meeting entitled "Genetic Analysis: Model Organisms to Human Biology" to examine the future role of genetic research. (Because of time limitations, the meeting was unable to cover the substantial contributions and future potential of research on model prokaryotic organisms.) In fact, the potential of model-organism-based studies has grown substantially in recent years. The genomics revolution has revealed an underlying unity between the cells and tissues of eukaryotic organisms from yeast to humans. No uniquely human biological mechanisms have yet come to light. This common evolutionary heritage makes it possible to use genetically tractable organisms to model important aspects of human medical disorders such as cancer, birth defects, neurological dysfunction, reproductive failure, malnutrition, and aging in systems amenable to rapid and powerful experimentation. Applying model systems in this way will allow us to identify common genes, proteins, and processes that underlie human medical conditions. It will allow us to systematically decipher the gene-gene and gene-environment interactions that influence complex multigenic disorders. Above all, disease models have the potential to address a growing gap between our ability to collect human genetic data and to productively interpret and apply it. If model organism research is supported with these goals in mind, we can look forward to diagnosing and treating human disease using information from multiple systems and to a medical science built on the unified history of life on earth.

Original languageEnglish (US)
Pages (from-to)2025-2032
Number of pages8
JournalGenetics
Volume172
Issue number4
StatePublished - Apr 2006
Externally publishedYes

Fingerprint

Genetic Models
Yeasts
Gene-Environment Interaction
Genetic Research
Medical Genetics
Eukaryotic Cells
Genomics
Research
Information Systems
Diptera
Malnutrition
Genes
Genome
Technology
Bacteria
Neoplasms
Proteins

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Cite this

Spradling, A., Ganetsky, B., Hieter, P., Johnston, M., Olson, M., Orr-Weaver, T., ... Waterston, R. (2006). New roles for model genetic organisms in understanding and treating human disease: Report from the 2006 Genetics Society of America meeting. Genetics, 172(4), 2025-2032.

New roles for model genetic organisms in understanding and treating human disease : Report from the 2006 Genetics Society of America meeting. / Spradling, Allan; Ganetsky, Barry; Hieter, Phil; Johnston, Mark; Olson, Maynard; Orr-Weaver, Terry; Rossant, Janet; Sanchez, Alejandro; Waterston, Robert.

In: Genetics, Vol. 172, No. 4, 04.2006, p. 2025-2032.

Research output: Contribution to journalArticle

Spradling, A, Ganetsky, B, Hieter, P, Johnston, M, Olson, M, Orr-Weaver, T, Rossant, J, Sanchez, A & Waterston, R 2006, 'New roles for model genetic organisms in understanding and treating human disease: Report from the 2006 Genetics Society of America meeting', Genetics, vol. 172, no. 4, pp. 2025-2032.
Spradling A, Ganetsky B, Hieter P, Johnston M, Olson M, Orr-Weaver T et al. New roles for model genetic organisms in understanding and treating human disease: Report from the 2006 Genetics Society of America meeting. Genetics. 2006 Apr;172(4):2025-2032.
Spradling, Allan ; Ganetsky, Barry ; Hieter, Phil ; Johnston, Mark ; Olson, Maynard ; Orr-Weaver, Terry ; Rossant, Janet ; Sanchez, Alejandro ; Waterston, Robert. / New roles for model genetic organisms in understanding and treating human disease : Report from the 2006 Genetics Society of America meeting. In: Genetics. 2006 ; Vol. 172, No. 4. pp. 2025-2032.
@article{a4bc6ff48ff94fe3b2e83aa698b1ccbf,
title = "New roles for model genetic organisms in understanding and treating human disease: Report from the 2006 Genetics Society of America meeting",
abstract = "Fundamental biological knowledge and the technology to acquire it have been immeasurably advanced by past efforts to understand and manipulate the genomes of model organisms. Has the utility of bacteria, yeast, worms, flies, mice, plants, and other models now peaked and are humans poised to become the model organism of the future? The Genetics Society of America recently convened its 2006 meeting entitled {"}Genetic Analysis: Model Organisms to Human Biology{"} to examine the future role of genetic research. (Because of time limitations, the meeting was unable to cover the substantial contributions and future potential of research on model prokaryotic organisms.) In fact, the potential of model-organism-based studies has grown substantially in recent years. The genomics revolution has revealed an underlying unity between the cells and tissues of eukaryotic organisms from yeast to humans. No uniquely human biological mechanisms have yet come to light. This common evolutionary heritage makes it possible to use genetically tractable organisms to model important aspects of human medical disorders such as cancer, birth defects, neurological dysfunction, reproductive failure, malnutrition, and aging in systems amenable to rapid and powerful experimentation. Applying model systems in this way will allow us to identify common genes, proteins, and processes that underlie human medical conditions. It will allow us to systematically decipher the gene-gene and gene-environment interactions that influence complex multigenic disorders. Above all, disease models have the potential to address a growing gap between our ability to collect human genetic data and to productively interpret and apply it. If model organism research is supported with these goals in mind, we can look forward to diagnosing and treating human disease using information from multiple systems and to a medical science built on the unified history of life on earth.",
author = "Allan Spradling and Barry Ganetsky and Phil Hieter and Mark Johnston and Maynard Olson and Terry Orr-Weaver and Janet Rossant and Alejandro Sanchez and Robert Waterston",
year = "2006",
month = "4",
language = "English (US)",
volume = "172",
pages = "2025--2032",
journal = "Genetics",
issn = "0016-6731",
publisher = "Genetics Society of America",
number = "4",

}

TY - JOUR

T1 - New roles for model genetic organisms in understanding and treating human disease

T2 - Report from the 2006 Genetics Society of America meeting

AU - Spradling, Allan

AU - Ganetsky, Barry

AU - Hieter, Phil

AU - Johnston, Mark

AU - Olson, Maynard

AU - Orr-Weaver, Terry

AU - Rossant, Janet

AU - Sanchez, Alejandro

AU - Waterston, Robert

PY - 2006/4

Y1 - 2006/4

N2 - Fundamental biological knowledge and the technology to acquire it have been immeasurably advanced by past efforts to understand and manipulate the genomes of model organisms. Has the utility of bacteria, yeast, worms, flies, mice, plants, and other models now peaked and are humans poised to become the model organism of the future? The Genetics Society of America recently convened its 2006 meeting entitled "Genetic Analysis: Model Organisms to Human Biology" to examine the future role of genetic research. (Because of time limitations, the meeting was unable to cover the substantial contributions and future potential of research on model prokaryotic organisms.) In fact, the potential of model-organism-based studies has grown substantially in recent years. The genomics revolution has revealed an underlying unity between the cells and tissues of eukaryotic organisms from yeast to humans. No uniquely human biological mechanisms have yet come to light. This common evolutionary heritage makes it possible to use genetically tractable organisms to model important aspects of human medical disorders such as cancer, birth defects, neurological dysfunction, reproductive failure, malnutrition, and aging in systems amenable to rapid and powerful experimentation. Applying model systems in this way will allow us to identify common genes, proteins, and processes that underlie human medical conditions. It will allow us to systematically decipher the gene-gene and gene-environment interactions that influence complex multigenic disorders. Above all, disease models have the potential to address a growing gap between our ability to collect human genetic data and to productively interpret and apply it. If model organism research is supported with these goals in mind, we can look forward to diagnosing and treating human disease using information from multiple systems and to a medical science built on the unified history of life on earth.

AB - Fundamental biological knowledge and the technology to acquire it have been immeasurably advanced by past efforts to understand and manipulate the genomes of model organisms. Has the utility of bacteria, yeast, worms, flies, mice, plants, and other models now peaked and are humans poised to become the model organism of the future? The Genetics Society of America recently convened its 2006 meeting entitled "Genetic Analysis: Model Organisms to Human Biology" to examine the future role of genetic research. (Because of time limitations, the meeting was unable to cover the substantial contributions and future potential of research on model prokaryotic organisms.) In fact, the potential of model-organism-based studies has grown substantially in recent years. The genomics revolution has revealed an underlying unity between the cells and tissues of eukaryotic organisms from yeast to humans. No uniquely human biological mechanisms have yet come to light. This common evolutionary heritage makes it possible to use genetically tractable organisms to model important aspects of human medical disorders such as cancer, birth defects, neurological dysfunction, reproductive failure, malnutrition, and aging in systems amenable to rapid and powerful experimentation. Applying model systems in this way will allow us to identify common genes, proteins, and processes that underlie human medical conditions. It will allow us to systematically decipher the gene-gene and gene-environment interactions that influence complex multigenic disorders. Above all, disease models have the potential to address a growing gap between our ability to collect human genetic data and to productively interpret and apply it. If model organism research is supported with these goals in mind, we can look forward to diagnosing and treating human disease using information from multiple systems and to a medical science built on the unified history of life on earth.

UR - http://www.scopus.com/inward/record.url?scp=33646185789&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33646185789&partnerID=8YFLogxK

M3 - Article

C2 - 16636111

AN - SCOPUS:33646185789

VL - 172

SP - 2025

EP - 2032

JO - Genetics

JF - Genetics

SN - 0016-6731

IS - 4

ER -