@article{4cbd44e8497e427faca69fab93213140,
title = "New roles for desmin in the maintenance of muscle homeostasis",
abstract = "Desmin is the primary intermediate filament (IF) of cardiac, skeletal, and smooth muscle. By linking the contractile myofibrils to the sarcolemma and cellular organelles, desmin IF contributes to muscle structural and cellular integrity, force transmission, and mitochondrial homeostasis. Mutations in desmin cause myofibril misalignment, mitochondrial dysfunction, and impaired mechanical integrity leading to cardiac and skeletal myopathies in humans, often characterized by the accumulation of protein aggregates. Recent evidence indicates that desmin filaments also regulate proteostasis and cell size. In skeletal muscle, changes in desmin filament dynamics can facilitate catabolic events as an adaptive response to a changing environment. In addition, post-translational modifications of desmin and its misfolding in the heart have emerged as key determinants of homeostasis and disease. In this review, we provide an overview of the structural and cellular roles of desmin and propose new models for its novel functions in preserving the homeostasis of striated muscles.",
keywords = "GSK3, desmin intermediate filaments, heart failure, metabolism, muscle atrophy, protein degradation, protein misfolding",
author = "Giulio Agnetti and Harald Herrmann and Shenhav Cohen",
note = "Funding Information: This project was supported by Leducq Foundation Network Grant {\textquoteleft}Cytoskeletal Regulation of Cardiomyocyte, Homeostasis in Health and Disease{\textquoteright} (#20CVD01), AHA 18TPA34170382 Women{\textquoteright}s Board of the AHA Greater Washington Region, The Magic that Matters Foundation, Zegar Family Foundation, AlmaIdea project and R.F.O unibo to GA, and by grants from The Israel Science Foundation (no. 623/15), the Niedersachsen‐Deutsche (no. ZN3008), and the Israel Ministry of Science, Technology and Space (grant no. 2015‐3‐74) to SC. Additional funds have been received from the Russell Berrie Nanotechnology Institute, Technion to SC. Funding Information: The authors are extremely thankful to Dr. Robert Bloch (University of Maryland School of Medicine, Baltimore, USA) for critically reading this manuscript and for providing valuable insights and suggestions. This project was supported by Leducq Foundation Network Grant {\textquoteleft}Cytoskeletal Regulation of Cardiomyocyte, Homeostasis in Health and Disease{\textquoteright} (#20CVD01), AHA 18TPA34170382 Women{\textquoteright}s Board of the AHA Greater Washington Region, The Magic that Matters Foundation, Zegar Family Foundation, AlmaIdea project and R.F.O unibo to GA, and by grants from The Israel Science Foundation (no. 623/15), the Niedersachsen-Deutsche (no. ZN3008), and the Israel Ministry of Science, Technology and Space (grant no. 2015-3-74) to SC. Additional funds have been received from the Russell Berrie Nanotechnology Institute, Technion to SC. Publisher Copyright: {\textcopyright} 2021 Federation of European Biochemical Societies.",
year = "2022",
month = may,
doi = "10.1111/febs.15864",
language = "English (US)",
volume = "289",
pages = "2755--2770",
journal = "FEBS Journal",
issn = "1742-464X",
publisher = "Wiley-Blackwell",
number = "10",
}