A new model for testing the ability of cancer chemotherapeutic agents to inhibit androgen induced growth in the ventral prostate of castrated rats has been developed. This system involves the ability of drugs to inhibit the 20 fold stimulation observed in the rate of DNA synthesis in castrated rats receiving exogenous testosterone propionate for 3 days. It has been determined that a peak occurs in the rate of DNA synthesis 72 hr after an initial injection of testosterone propionate, and this has been used as an index to measure the ability of various cancer chemotherapeutic agents to inhibit this process. 5 Fluorouracil and doxorubicin (adriamycin) were effective drugs in this regard, and cyclophosphamide, CCNU, and streptozotocin were essentially without effectiveness on DNA synthesis. The merits of this model as a screen in determining the effects of these drugs on the growth of the prostate are discussed.
|Original language||English (US)|
|Number of pages||10|
|State||Published - Jan 1 1975|
ASJC Scopus subject areas