New method for mechanistic studies of cardiomyoplasty: Three-dimensional MRI reconstructions

Peter W. Cho, Howard R. Levin, Christopher C. Moore, Joshua E. Tsitlik, Elliot R. McVeigh, Timothy J. Gardner, Michael A. Acker

Research output: Contribution to journalArticle

Abstract

The imaging modalities used to study the mechanism of cardiomyoplasty, such as echocardiography and radionuclide scintigraphy, are seriously limited by their two-dimensional format. Radiofrequency-pulse-tagged magnetic resonance imaging was used to generate three-dimensional reconstructions of the left ventricle throughout the cardiac cycle after cardiomyoplasty. In 2 dogs that had undergone conditioned, right anterior cardiomyoplasty, wrap stimulation with alternating heartbeats was found to produce marked translation of the left ventricle in the short-axis plane, rotation around the long axis, and displacement along the long axis with net long-axis compression; there was no augmentation of radial squeeze. The findings from this study suggest that any Systolic augmentation produced by the right anterior wrap is due primarily to long-axis compression. Our study demonstrates a new, more accurate technique of assessing the mechanical effects of cardiomyoplasty in three dimensions, thus permitting a more rational optimization of wrap configurations, and emphasizes the perils of using standard two-dimensional imaging modalities in this setting of exaggerated three-dimensional motion.

Original languageEnglish (US)
Pages (from-to)1605-1611
Number of pages7
JournalAnnals of Thoracic Surgery
Volume57
Issue number6
StatePublished - Jun 1994

ASJC Scopus subject areas

  • Surgery
  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'New method for mechanistic studies of cardiomyoplasty: Three-dimensional MRI reconstructions'. Together they form a unique fingerprint.

  • Cite this

    Cho, P. W., Levin, H. R., Moore, C. C., Tsitlik, J. E., McVeigh, E. R., Gardner, T. J., & Acker, M. A. (1994). New method for mechanistic studies of cardiomyoplasty: Three-dimensional MRI reconstructions. Annals of Thoracic Surgery, 57(6), 1605-1611.