New loci associated with kidney function and chronic kidney disease

Anna Köttgen, Cristian Pattaro, Carsten A. Böger, Christian Fuchsberger, Matthias Olden, Nicole L. Glazer, Afshin Parsa, Xiaoyi Gao, Qiong Yang, Albert V. Smith, Jeffrey R. O'Connel, Man Li, Helena Schmidt, Toshiko Tanaka, Aaron Isaacs, Shamika Ketkar, Shih Jen Hwang, Andrew D. Johnson, Abbas Dehghan, Alexander Teumer & 112 others Guillaume Paré, Elizabeth J. Atkinson, Tanja Zeller, Kurt Lohman, Marilyn C. Cornelis, Nicole M. Probst-Hensch, Florian Kronenberg, Anke Tönjes, Caroline Hayward, Thor Aspelund, Gudny Eiriksdottir, Lenore J. Launer, Tamara B. Harris, Evadnie Rampersaud, Braxton D. Mitchel, Dan Arking, Eric Boerwinkle, Maksim Struchalin, Margherita Cavalieri, Andrew Singleton, Francesco Giallauria, Jeffrey Metter, Ian H. De Boer, Talin Haritunians, Thomas Lumley, David Siscovick, Bruce M. Psaty, M. CarolaZillikens, Ben A. Oostra, Mary Feitosa, Michael Province, Mariza De Andrade, Stephen T. Turner, Arne Schillert, Andreas Ziegler, Philipp S. Wild, Renate B. Schnabel, Sandra Wilde, Thomas F. Munzel, Tennille S. Leak, Thomas Illig, Norman Klopp, Christa Meisinger, H. Erich Wichmann, Wolfgang Koenig, Lina Zgaga, Tatijana Zemunik, Ivana Kolcic, Cosetta Minelli, Frank B. Hu, Åsa Johansson, Wilmar Igl, Ghazal Zaboli, Sarah H. Wild, Alan F. Wright, Harry Campbell, David Ellinghaus, Stefan Schreiber, Yurii S. Aulchenko, Janine F. Felix, Fernando Rivadeneira, Andre G. Uitterlinden, Albert Hofman, Medea Imboden, Dorothea Nitsch, Anita Brandstätter, Barbara Kollerits, Lyudmyla Kedenko, Reedik Mägi, Michael Stumvoll, Peter Kovacs, Mladen Boban, Susan Campbell, Karlhans Endlich, Henry Völzke, Heyo K. Kroemer, Matthias Nauck, Uwe Völker, Ozren Polasek, Veronique Vitart, Sunita Badola, Alexander N. Parker, Paul M. Ridker, Sharon L R Kardia, Stefan Blankenberg, Yongmei Liu, Gary C. Curhan, Andre Franke, Thierry Rochat, Bernhard Paulweber, Inga Prokopenko, Wei Wang, Vilmundur Gudnason, Alan R. Shuldine, Josef Coresh, Reinhold Schmidt, Luigi Ferrucci, Michael G. Shlipak, Cornelia M. Van Duijn, Ingrid Borecki, Bernhard K. Krämer, Igor Rudan, Ulf Gyllensten, James F. Wilson, Jacqueline C. Witteman, Peter P. Pramstaller, Rainer Rettig, Nick Hastie, Daniel I. Chasman, W. H. Kao, Iris M. Heid, Caroline S. Fox

Research output: Contribution to journalArticle

Abstract

Chronic kidney disease (CKD) is a significant public health problem, and recent genetic studies have identified common CKD susceptibility variants. The CKDGen consortium performed a meta-analysis of genome-wide association data in 67,093 individuals of European ancestry from 20 predominantly population-based studies in order to identify new susceptibility loci for reduced renal function as estimated by serum creatinine (eGFRcrea), serum cystatin c (eGFRcys) and CKD (eGFRcrea 60 ml/min/1.73 m 2; n = 5,807 individuals with CKD (cases)). Follow-up of the 23 new genome-wide-significant loci (P 5 × 10 8) in 22,982 replication samples identified 13 new loci affecting renal function and CKD (in or near LASS2, GCKR, ALMS1, TFDP2, DAB2, SLC34A1, VEGFA, PRKAG2, PIP5K1B, ATXN2, DACH1, UBE2Q2 and SLC7A9) and 7 loci suspected to affect creatinine production and secretion (CPS1, SLC22A2, TMEM60, WDR37, SLC6A13, WDR72 and BCAS3). These results further our understanding of the biologic mechanisms of kidney function by identifying loci that potentially influence nephrogenesis, podocyte function, angiogenesis, solute transport and metabolic functions of the kidney.

Original languageEnglish (US)
Pages (from-to)376-384
Number of pages9
JournalNature Genetics
Volume42
Issue number5
DOIs
StatePublished - May 2010

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Chronic Renal Insufficiency
Kidney
Creatinine
Genome
Cystatins
Podocytes
Disease Susceptibility
Serum
Meta-Analysis
Public Health
Population

ASJC Scopus subject areas

  • Genetics

Cite this

Köttgen, A., Pattaro, C., Böger, C. A., Fuchsberger, C., Olden, M., Glazer, N. L., ... Fox, C. S. (2010). New loci associated with kidney function and chronic kidney disease. Nature Genetics, 42(5), 376-384. https://doi.org/10.1038/ng.568

New loci associated with kidney function and chronic kidney disease. / Köttgen, Anna; Pattaro, Cristian; Böger, Carsten A.; Fuchsberger, Christian; Olden, Matthias; Glazer, Nicole L.; Parsa, Afshin; Gao, Xiaoyi; Yang, Qiong; Smith, Albert V.; O'Connel, Jeffrey R.; Li, Man; Schmidt, Helena; Tanaka, Toshiko; Isaacs, Aaron; Ketkar, Shamika; Hwang, Shih Jen; Johnson, Andrew D.; Dehghan, Abbas; Teumer, Alexander; Paré, Guillaume; Atkinson, Elizabeth J.; Zeller, Tanja; Lohman, Kurt; Cornelis, Marilyn C.; Probst-Hensch, Nicole M.; Kronenberg, Florian; Tönjes, Anke; Hayward, Caroline; Aspelund, Thor; Eiriksdottir, Gudny; Launer, Lenore J.; Harris, Tamara B.; Rampersaud, Evadnie; Mitchel, Braxton D.; Arking, Dan; Boerwinkle, Eric; Struchalin, Maksim; Cavalieri, Margherita; Singleton, Andrew; Giallauria, Francesco; Metter, Jeffrey; De Boer, Ian H.; Haritunians, Talin; Lumley, Thomas; Siscovick, David; Psaty, Bruce M.; CarolaZillikens, M.; Oostra, Ben A.; Feitosa, Mary; Province, Michael; Andrade, Mariza De; Turner, Stephen T.; Schillert, Arne; Ziegler, Andreas; Wild, Philipp S.; Schnabel, Renate B.; Wilde, Sandra; Munzel, Thomas F.; Leak, Tennille S.; Illig, Thomas; Klopp, Norman; Meisinger, Christa; Wichmann, H. Erich; Koenig, Wolfgang; Zgaga, Lina; Zemunik, Tatijana; Kolcic, Ivana; Minelli, Cosetta; Hu, Frank B.; Johansson, Åsa; Igl, Wilmar; Zaboli, Ghazal; Wild, Sarah H.; Wright, Alan F.; Campbell, Harry; Ellinghaus, David; Schreiber, Stefan; Aulchenko, Yurii S.; Felix, Janine F.; Rivadeneira, Fernando; Uitterlinden, Andre G.; Hofman, Albert; Imboden, Medea; Nitsch, Dorothea; Brandstätter, Anita; Kollerits, Barbara; Kedenko, Lyudmyla; Mägi, Reedik; Stumvoll, Michael; Kovacs, Peter; Boban, Mladen; Campbell, Susan; Endlich, Karlhans; Völzke, Henry; Kroemer, Heyo K.; Nauck, Matthias; Völker, Uwe; Polasek, Ozren; Vitart, Veronique; Badola, Sunita; Parker, Alexander N.; Ridker, Paul M.; Kardia, Sharon L R; Blankenberg, Stefan; Liu, Yongmei; Curhan, Gary C.; Franke, Andre; Rochat, Thierry; Paulweber, Bernhard; Prokopenko, Inga; Wang, Wei; Gudnason, Vilmundur; Shuldine, Alan R.; Coresh, Josef; Schmidt, Reinhold; Ferrucci, Luigi; Shlipak, Michael G.; Van Duijn, Cornelia M.; Borecki, Ingrid; Krämer, Bernhard K.; Rudan, Igor; Gyllensten, Ulf; Wilson, James F.; Witteman, Jacqueline C.; Pramstaller, Peter P.; Rettig, Rainer; Hastie, Nick; Chasman, Daniel I.; Kao, W. H.; Heid, Iris M.; Fox, Caroline S.

In: Nature Genetics, Vol. 42, No. 5, 05.2010, p. 376-384.

Research output: Contribution to journalArticle

Köttgen, A, Pattaro, C, Böger, CA, Fuchsberger, C, Olden, M, Glazer, NL, Parsa, A, Gao, X, Yang, Q, Smith, AV, O'Connel, JR, Li, M, Schmidt, H, Tanaka, T, Isaacs, A, Ketkar, S, Hwang, SJ, Johnson, AD, Dehghan, A, Teumer, A, Paré, G, Atkinson, EJ, Zeller, T, Lohman, K, Cornelis, MC, Probst-Hensch, NM, Kronenberg, F, Tönjes, A, Hayward, C, Aspelund, T, Eiriksdottir, G, Launer, LJ, Harris, TB, Rampersaud, E, Mitchel, BD, Arking, D, Boerwinkle, E, Struchalin, M, Cavalieri, M, Singleton, A, Giallauria, F, Metter, J, De Boer, IH, Haritunians, T, Lumley, T, Siscovick, D, Psaty, BM, CarolaZillikens, M, Oostra, BA, Feitosa, M, Province, M, Andrade, MD, Turner, ST, Schillert, A, Ziegler, A, Wild, PS, Schnabel, RB, Wilde, S, Munzel, TF, Leak, TS, Illig, T, Klopp, N, Meisinger, C, Wichmann, HE, Koenig, W, Zgaga, L, Zemunik, T, Kolcic, I, Minelli, C, Hu, FB, Johansson, Å, Igl, W, Zaboli, G, Wild, SH, Wright, AF, Campbell, H, Ellinghaus, D, Schreiber, S, Aulchenko, YS, Felix, JF, Rivadeneira, F, Uitterlinden, AG, Hofman, A, Imboden, M, Nitsch, D, Brandstätter, A, Kollerits, B, Kedenko, L, Mägi, R, Stumvoll, M, Kovacs, P, Boban, M, Campbell, S, Endlich, K, Völzke, H, Kroemer, HK, Nauck, M, Völker, U, Polasek, O, Vitart, V, Badola, S, Parker, AN, Ridker, PM, Kardia, SLR, Blankenberg, S, Liu, Y, Curhan, GC, Franke, A, Rochat, T, Paulweber, B, Prokopenko, I, Wang, W, Gudnason, V, Shuldine, AR, Coresh, J, Schmidt, R, Ferrucci, L, Shlipak, MG, Van Duijn, CM, Borecki, I, Krämer, BK, Rudan, I, Gyllensten, U, Wilson, JF, Witteman, JC, Pramstaller, PP, Rettig, R, Hastie, N, Chasman, DI, Kao, WH, Heid, IM & Fox, CS 2010, 'New loci associated with kidney function and chronic kidney disease', Nature Genetics, vol. 42, no. 5, pp. 376-384. https://doi.org/10.1038/ng.568
Köttgen A, Pattaro C, Böger CA, Fuchsberger C, Olden M, Glazer NL et al. New loci associated with kidney function and chronic kidney disease. Nature Genetics. 2010 May;42(5):376-384. https://doi.org/10.1038/ng.568
Köttgen, Anna ; Pattaro, Cristian ; Böger, Carsten A. ; Fuchsberger, Christian ; Olden, Matthias ; Glazer, Nicole L. ; Parsa, Afshin ; Gao, Xiaoyi ; Yang, Qiong ; Smith, Albert V. ; O'Connel, Jeffrey R. ; Li, Man ; Schmidt, Helena ; Tanaka, Toshiko ; Isaacs, Aaron ; Ketkar, Shamika ; Hwang, Shih Jen ; Johnson, Andrew D. ; Dehghan, Abbas ; Teumer, Alexander ; Paré, Guillaume ; Atkinson, Elizabeth J. ; Zeller, Tanja ; Lohman, Kurt ; Cornelis, Marilyn C. ; Probst-Hensch, Nicole M. ; Kronenberg, Florian ; Tönjes, Anke ; Hayward, Caroline ; Aspelund, Thor ; Eiriksdottir, Gudny ; Launer, Lenore J. ; Harris, Tamara B. ; Rampersaud, Evadnie ; Mitchel, Braxton D. ; Arking, Dan ; Boerwinkle, Eric ; Struchalin, Maksim ; Cavalieri, Margherita ; Singleton, Andrew ; Giallauria, Francesco ; Metter, Jeffrey ; De Boer, Ian H. ; Haritunians, Talin ; Lumley, Thomas ; Siscovick, David ; Psaty, Bruce M. ; CarolaZillikens, M. ; Oostra, Ben A. ; Feitosa, Mary ; Province, Michael ; Andrade, Mariza De ; Turner, Stephen T. ; Schillert, Arne ; Ziegler, Andreas ; Wild, Philipp S. ; Schnabel, Renate B. ; Wilde, Sandra ; Munzel, Thomas F. ; Leak, Tennille S. ; Illig, Thomas ; Klopp, Norman ; Meisinger, Christa ; Wichmann, H. Erich ; Koenig, Wolfgang ; Zgaga, Lina ; Zemunik, Tatijana ; Kolcic, Ivana ; Minelli, Cosetta ; Hu, Frank B. ; Johansson, Åsa ; Igl, Wilmar ; Zaboli, Ghazal ; Wild, Sarah H. ; Wright, Alan F. ; Campbell, Harry ; Ellinghaus, David ; Schreiber, Stefan ; Aulchenko, Yurii S. ; Felix, Janine F. ; Rivadeneira, Fernando ; Uitterlinden, Andre G. ; Hofman, Albert ; Imboden, Medea ; Nitsch, Dorothea ; Brandstätter, Anita ; Kollerits, Barbara ; Kedenko, Lyudmyla ; Mägi, Reedik ; Stumvoll, Michael ; Kovacs, Peter ; Boban, Mladen ; Campbell, Susan ; Endlich, Karlhans ; Völzke, Henry ; Kroemer, Heyo K. ; Nauck, Matthias ; Völker, Uwe ; Polasek, Ozren ; Vitart, Veronique ; Badola, Sunita ; Parker, Alexander N. ; Ridker, Paul M. ; Kardia, Sharon L R ; Blankenberg, Stefan ; Liu, Yongmei ; Curhan, Gary C. ; Franke, Andre ; Rochat, Thierry ; Paulweber, Bernhard ; Prokopenko, Inga ; Wang, Wei ; Gudnason, Vilmundur ; Shuldine, Alan R. ; Coresh, Josef ; Schmidt, Reinhold ; Ferrucci, Luigi ; Shlipak, Michael G. ; Van Duijn, Cornelia M. ; Borecki, Ingrid ; Krämer, Bernhard K. ; Rudan, Igor ; Gyllensten, Ulf ; Wilson, James F. ; Witteman, Jacqueline C. ; Pramstaller, Peter P. ; Rettig, Rainer ; Hastie, Nick ; Chasman, Daniel I. ; Kao, W. H. ; Heid, Iris M. ; Fox, Caroline S. / New loci associated with kidney function and chronic kidney disease. In: Nature Genetics. 2010 ; Vol. 42, No. 5. pp. 376-384.
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abstract = "Chronic kidney disease (CKD) is a significant public health problem, and recent genetic studies have identified common CKD susceptibility variants. The CKDGen consortium performed a meta-analysis of genome-wide association data in 67,093 individuals of European ancestry from 20 predominantly population-based studies in order to identify new susceptibility loci for reduced renal function as estimated by serum creatinine (eGFRcrea), serum cystatin c (eGFRcys) and CKD (eGFRcrea 60 ml/min/1.73 m 2; n = 5,807 individuals with CKD (cases)). Follow-up of the 23 new genome-wide-significant loci (P 5 × 10 8) in 22,982 replication samples identified 13 new loci affecting renal function and CKD (in or near LASS2, GCKR, ALMS1, TFDP2, DAB2, SLC34A1, VEGFA, PRKAG2, PIP5K1B, ATXN2, DACH1, UBE2Q2 and SLC7A9) and 7 loci suspected to affect creatinine production and secretion (CPS1, SLC22A2, TMEM60, WDR37, SLC6A13, WDR72 and BCAS3). These results further our understanding of the biologic mechanisms of kidney function by identifying loci that potentially influence nephrogenesis, podocyte function, angiogenesis, solute transport and metabolic functions of the kidney.",
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T1 - New loci associated with kidney function and chronic kidney disease

AU - Köttgen, Anna

AU - Pattaro, Cristian

AU - Böger, Carsten A.

AU - Fuchsberger, Christian

AU - Olden, Matthias

AU - Glazer, Nicole L.

AU - Parsa, Afshin

AU - Gao, Xiaoyi

AU - Yang, Qiong

AU - Smith, Albert V.

AU - O'Connel, Jeffrey R.

AU - Li, Man

AU - Schmidt, Helena

AU - Tanaka, Toshiko

AU - Isaacs, Aaron

AU - Ketkar, Shamika

AU - Hwang, Shih Jen

AU - Johnson, Andrew D.

AU - Dehghan, Abbas

AU - Teumer, Alexander

AU - Paré, Guillaume

AU - Atkinson, Elizabeth J.

AU - Zeller, Tanja

AU - Lohman, Kurt

AU - Cornelis, Marilyn C.

AU - Probst-Hensch, Nicole M.

AU - Kronenberg, Florian

AU - Tönjes, Anke

AU - Hayward, Caroline

AU - Aspelund, Thor

AU - Eiriksdottir, Gudny

AU - Launer, Lenore J.

AU - Harris, Tamara B.

AU - Rampersaud, Evadnie

AU - Mitchel, Braxton D.

AU - Arking, Dan

AU - Boerwinkle, Eric

AU - Struchalin, Maksim

AU - Cavalieri, Margherita

AU - Singleton, Andrew

AU - Giallauria, Francesco

AU - Metter, Jeffrey

AU - De Boer, Ian H.

AU - Haritunians, Talin

AU - Lumley, Thomas

AU - Siscovick, David

AU - Psaty, Bruce M.

AU - CarolaZillikens, M.

AU - Oostra, Ben A.

AU - Feitosa, Mary

AU - Province, Michael

AU - Andrade, Mariza De

AU - Turner, Stephen T.

AU - Schillert, Arne

AU - Ziegler, Andreas

AU - Wild, Philipp S.

AU - Schnabel, Renate B.

AU - Wilde, Sandra

AU - Munzel, Thomas F.

AU - Leak, Tennille S.

AU - Illig, Thomas

AU - Klopp, Norman

AU - Meisinger, Christa

AU - Wichmann, H. Erich

AU - Koenig, Wolfgang

AU - Zgaga, Lina

AU - Zemunik, Tatijana

AU - Kolcic, Ivana

AU - Minelli, Cosetta

AU - Hu, Frank B.

AU - Johansson, Åsa

AU - Igl, Wilmar

AU - Zaboli, Ghazal

AU - Wild, Sarah H.

AU - Wright, Alan F.

AU - Campbell, Harry

AU - Ellinghaus, David

AU - Schreiber, Stefan

AU - Aulchenko, Yurii S.

AU - Felix, Janine F.

AU - Rivadeneira, Fernando

AU - Uitterlinden, Andre G.

AU - Hofman, Albert

AU - Imboden, Medea

AU - Nitsch, Dorothea

AU - Brandstätter, Anita

AU - Kollerits, Barbara

AU - Kedenko, Lyudmyla

AU - Mägi, Reedik

AU - Stumvoll, Michael

AU - Kovacs, Peter

AU - Boban, Mladen

AU - Campbell, Susan

AU - Endlich, Karlhans

AU - Völzke, Henry

AU - Kroemer, Heyo K.

AU - Nauck, Matthias

AU - Völker, Uwe

AU - Polasek, Ozren

AU - Vitart, Veronique

AU - Badola, Sunita

AU - Parker, Alexander N.

AU - Ridker, Paul M.

AU - Kardia, Sharon L R

AU - Blankenberg, Stefan

AU - Liu, Yongmei

AU - Curhan, Gary C.

AU - Franke, Andre

AU - Rochat, Thierry

AU - Paulweber, Bernhard

AU - Prokopenko, Inga

AU - Wang, Wei

AU - Gudnason, Vilmundur

AU - Shuldine, Alan R.

AU - Coresh, Josef

AU - Schmidt, Reinhold

AU - Ferrucci, Luigi

AU - Shlipak, Michael G.

AU - Van Duijn, Cornelia M.

AU - Borecki, Ingrid

AU - Krämer, Bernhard K.

AU - Rudan, Igor

AU - Gyllensten, Ulf

AU - Wilson, James F.

AU - Witteman, Jacqueline C.

AU - Pramstaller, Peter P.

AU - Rettig, Rainer

AU - Hastie, Nick

AU - Chasman, Daniel I.

AU - Kao, W. H.

AU - Heid, Iris M.

AU - Fox, Caroline S.

PY - 2010/5

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N2 - Chronic kidney disease (CKD) is a significant public health problem, and recent genetic studies have identified common CKD susceptibility variants. The CKDGen consortium performed a meta-analysis of genome-wide association data in 67,093 individuals of European ancestry from 20 predominantly population-based studies in order to identify new susceptibility loci for reduced renal function as estimated by serum creatinine (eGFRcrea), serum cystatin c (eGFRcys) and CKD (eGFRcrea 60 ml/min/1.73 m 2; n = 5,807 individuals with CKD (cases)). Follow-up of the 23 new genome-wide-significant loci (P 5 × 10 8) in 22,982 replication samples identified 13 new loci affecting renal function and CKD (in or near LASS2, GCKR, ALMS1, TFDP2, DAB2, SLC34A1, VEGFA, PRKAG2, PIP5K1B, ATXN2, DACH1, UBE2Q2 and SLC7A9) and 7 loci suspected to affect creatinine production and secretion (CPS1, SLC22A2, TMEM60, WDR37, SLC6A13, WDR72 and BCAS3). These results further our understanding of the biologic mechanisms of kidney function by identifying loci that potentially influence nephrogenesis, podocyte function, angiogenesis, solute transport and metabolic functions of the kidney.

AB - Chronic kidney disease (CKD) is a significant public health problem, and recent genetic studies have identified common CKD susceptibility variants. The CKDGen consortium performed a meta-analysis of genome-wide association data in 67,093 individuals of European ancestry from 20 predominantly population-based studies in order to identify new susceptibility loci for reduced renal function as estimated by serum creatinine (eGFRcrea), serum cystatin c (eGFRcys) and CKD (eGFRcrea 60 ml/min/1.73 m 2; n = 5,807 individuals with CKD (cases)). Follow-up of the 23 new genome-wide-significant loci (P 5 × 10 8) in 22,982 replication samples identified 13 new loci affecting renal function and CKD (in or near LASS2, GCKR, ALMS1, TFDP2, DAB2, SLC34A1, VEGFA, PRKAG2, PIP5K1B, ATXN2, DACH1, UBE2Q2 and SLC7A9) and 7 loci suspected to affect creatinine production and secretion (CPS1, SLC22A2, TMEM60, WDR37, SLC6A13, WDR72 and BCAS3). These results further our understanding of the biologic mechanisms of kidney function by identifying loci that potentially influence nephrogenesis, podocyte function, angiogenesis, solute transport and metabolic functions of the kidney.

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