New light on the integrin switch

Daniel J. Leahy

Research output: Contribution to journalReview articlepeer-review

Abstract

Recent structures of the integrin ectodomain and the cytoplasmic tail complex suggest a model for both "inside-out" and "outside-in" integrin signalling, whereby ligand binding and unclasping the cytoplasmic tails can shift integrin to a high-affinity form.

Original languageEnglish (US)
Pages (from-to)1152-1154
Number of pages3
JournalStructure
Volume10
Issue number9
DOIs
StatePublished - Sep 2002

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology

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