TY - JOUR
T1 - New Insights on the Basic Science of Bladder Exstrophy-epispadias Complex
AU - Hall, Saran A.
AU - Manyevitch, Roni
AU - Mistry, Preeya K.
AU - Wu, Wayland
AU - Gearhart, John P.
N1 - Publisher Copyright:
© 2020
PY - 2021/1
Y1 - 2021/1
N2 - The exstrophy-epispadias complex is a rare congenital anomaly presenting as a wide spectrum of disorders. The complex nature of this malformation leads to continuous investigations of the basic science concepts behind it. Elucidating these concepts allows one to fully understand the mechanisms behind the disease in order to improve diagnosis, management, and treatment ultimately leading to improvement in patient quality of life. Multiple technological advancements within the last 10 years have been made allowing for new studies to be conducted. Herein, the authors conduct a literature review of studies from 2009 to 2019, considering novel theories regarding the genetics, embryology, bladder, bony pelvis, prostate, and genitalia of patients with bladder exstrophy-epispadias complex.
AB - The exstrophy-epispadias complex is a rare congenital anomaly presenting as a wide spectrum of disorders. The complex nature of this malformation leads to continuous investigations of the basic science concepts behind it. Elucidating these concepts allows one to fully understand the mechanisms behind the disease in order to improve diagnosis, management, and treatment ultimately leading to improvement in patient quality of life. Multiple technological advancements within the last 10 years have been made allowing for new studies to be conducted. Herein, the authors conduct a literature review of studies from 2009 to 2019, considering novel theories regarding the genetics, embryology, bladder, bony pelvis, prostate, and genitalia of patients with bladder exstrophy-epispadias complex.
UR - http://www.scopus.com/inward/record.url?scp=85092921118&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85092921118&partnerID=8YFLogxK
U2 - 10.1016/j.urology.2020.10.004
DO - 10.1016/j.urology.2020.10.004
M3 - Article
C2 - 33049233
AN - SCOPUS:85092921118
SN - 0090-4295
VL - 147
SP - 256
EP - 263
JO - Urology
JF - Urology
ER -