New insights into the role of fatty acids in the pathogenesis and resolution of inflammatory bowel disease

Darla R. Shores, David G. Binion, Bruce A. Freeman, Paul R.S. Baker

Research output: Contribution to journalReview article

Abstract

Dietary and endogenously modified lipids modulate inflammation by functioning as intra- and intercellular signaling molecules. Proinflammatory lipid mediators such as the eicosanoids compete against the signaling actions of newly discovered modified fatty acids that act to resolve inflammation. In inflammatory bowel disease, multiple aberrancies in lipid metabolism have been discovered, which shed further light on the pathogenesis of intestinal inflammation. Mechanisms by which lipids modulate inflammation, abnormalities of lipid metabolism in the setting of inflammatory bowel disease, and potential therapeutic application of lipid derivatives in this setting are discussed. (Inflamm Bowel Dis 2010)

Original languageEnglish (US)
Pages (from-to)2192-2204
Number of pages13
JournalInflammatory bowel diseases
Volume17
Issue number10
DOIs
StatePublished - Oct 2011
Externally publishedYes

Keywords

  • fatty acids
  • inflammation
  • inflammatory bowel disease
  • metabolism
  • therapy

ASJC Scopus subject areas

  • Immunology and Allergy
  • Gastroenterology

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