New insights into the regulation and function of brain estrogen synthase (aromatase)

Jacques Balthazart, Gregory F. Ball

Research output: Contribution to journalArticle

Abstract

In the brain, conversion of androgens into estrogens by the enzyme aromatase (estrogen synthase) is a key mechanism by which testosterone regulates many physiological and behavioral processes, including the activation of male sexual behavior, brain sexual differentiation and negative feedback effects of steroid hormones on gonadotropin secretion. Studies on the distribution and regulation of brain aromatase have led to a new perspective on the control and function of this enzyme. A growing body of evidence indicates that the estrogen regulation of aromatase is, at least in part, trans-synaptic. Afferent catecholamine pathways appear to regulate aromatase activity in some brain areas and thereby provide a way for environmental cues to modulate this enzyme. The localization of aromatase in pre-synaptic boutons suggests possible roles for estrogens at the synapse.

Original languageEnglish (US)
Pages (from-to)243-249
Number of pages7
JournalTrends in Neurosciences
Volume21
Issue number6
DOIs
StatePublished - Jun 1 1998

Fingerprint

Aromatase
Brain
Estrogens
Enzymes
Physiological Phenomena
Afferent Pathways
Sex Differentiation
Presynaptic Terminals
Gonadotropins
Sexual Behavior
Synapses
Androgens
Catecholamines
Cues
Testosterone
Steroids
Hormones

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

New insights into the regulation and function of brain estrogen synthase (aromatase). / Balthazart, Jacques; Ball, Gregory F.

In: Trends in Neurosciences, Vol. 21, No. 6, 01.06.1998, p. 243-249.

Research output: Contribution to journalArticle

Balthazart, Jacques ; Ball, Gregory F. / New insights into the regulation and function of brain estrogen synthase (aromatase). In: Trends in Neurosciences. 1998 ; Vol. 21, No. 6. pp. 243-249.
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