New insights into the prevention and treatment of familial breast cancer

David M. Euhus

doi:10.1002/jso.21664

New insights into the prevention and treatment of familial breast cancer

David M. Euhus

Research output: Contribution to journal › Review article › peer-review

4 Scopus citations

Abstract

Individuals who inherit a deleterious mutation in BRCA1 or BRCA2 are at very high risk for breast cancer but there are several strategies available for successfully managing this risk. Breast cancers that develop in the context of germline BRCA gene mutation present challenges for management but also opportunities. DNA damaging agents, like cisplatin, and the new class of drugs called PARP inhibitors exploit the underlying defect in DNA damage repair to great effect.

Original language	English (US)
Pages (from-to)	294-298
Number of pages	5
Journal	Journal of Surgical Oncology
Volume	103
Issue number	4
DOIs	https://doi.org/10.1002/jso.21664
State	Published - Mar 15 2011
Externally published	Yes

Keywords

BRCA1
BRCA2
Chemoprevention
Cisplatin
Mastectomy
Oophorectomy
PARP inhibitors

ASJC Scopus subject areas

Surgery
Oncology

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10.1002/jso.21664

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abstract = "Individuals who inherit a deleterious mutation in BRCA1 or BRCA2 are at very high risk for breast cancer but there are several strategies available for successfully managing this risk. Breast cancers that develop in the context of germline BRCA gene mutation present challenges for management but also opportunities. DNA damaging agents, like cisplatin, and the new class of drugs called PARP inhibitors exploit the underlying defect in DNA damage repair to great effect.",

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AB - Individuals who inherit a deleterious mutation in BRCA1 or BRCA2 are at very high risk for breast cancer but there are several strategies available for successfully managing this risk. Breast cancers that develop in the context of germline BRCA gene mutation present challenges for management but also opportunities. DNA damaging agents, like cisplatin, and the new class of drugs called PARP inhibitors exploit the underlying defect in DNA damage repair to great effect.

KW - BRCA1

KW - BRCA2

KW - Chemoprevention

KW - Cisplatin

KW - Mastectomy

KW - Oophorectomy

KW - PARP inhibitors

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M3 - Review article

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New insights into the prevention and treatment of familial breast cancer

Abstract

Keywords

ASJC Scopus subject areas

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