New insights into the biology of osteocalcin

Meredith L. Zoch, Thomas Clemens, Ryan Riddle

Research output: Contribution to journalArticle

Abstract

Osteocalcin is among the most abundant proteins in bone and is produced exclusively by osteoblasts. Initially believed to be an inhibitor of bone mineralization, recent studies suggest a broader role for osteocalcin that extends to the regulation of whole body metabolism, reproduction, and cognition. Circulating undercarboxylated osteocalcin, which is regulated by insulin, acts in a feed-forward loop to increase β-cell proliferation as well as insulin production and secretion, while skeletal muscle and adipose tissue respond to osteocalcin by increasing their sensitivity to insulin. Osteocalcin also acts in the brain to increase neurotransmitter production and in the testes to stimulate testosterone production. At least one putative receptor for osteocalcin, Gprc6a, is expressed by adipose, skeletal muscle, and the Leydig cells of the testes and appears to mediate osteocalcin's effects in these tissues. In this review, we summarize these new discoveries, which suggest that the ability of osteocalcin to function both locally in bone and as a hormone depends on a novel post-translational mechanism that alters osteocalcin's affinity for the bone matrix and bioavailability. This article is part of a Special Issue entitled Bone and diabetes.

Original languageEnglish (US)
Pages (from-to)42-49
Number of pages8
JournalBone
Volume82
DOIs
StatePublished - Jan 1 2016

Fingerprint

Osteocalcin
Bone and Bones
Testis
Skeletal Muscle
Insulin
Physiologic Calcification
Bone Matrix
Aptitude
Leydig Cells
Osteoblasts
Muscle Cells
Cognition
Biological Availability
Reproduction
Neurotransmitter Agents
Insulin Resistance
Testosterone
Adipose Tissue
Cell Proliferation
Hormones

Keywords

  • Diabetes
  • Metabolism
  • Osteoblast
  • Osteocalcin

ASJC Scopus subject areas

  • Physiology
  • Endocrinology, Diabetes and Metabolism
  • Histology

Cite this

New insights into the biology of osteocalcin. / Zoch, Meredith L.; Clemens, Thomas; Riddle, Ryan.

In: Bone, Vol. 82, 01.01.2016, p. 42-49.

Research output: Contribution to journalArticle

Zoch, Meredith L. ; Clemens, Thomas ; Riddle, Ryan. / New insights into the biology of osteocalcin. In: Bone. 2016 ; Vol. 82. pp. 42-49.
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