New insights into store-independent Ca 2+ entry: Secretory pathway calcium ATPase 2 in normal physiology and cancer

Ming Ye Feng; Rajini Rao

doi:10.1038/ijos.2013.23

New insights into store-independent Ca 2+ entry: Secretory pathway calcium ATPase 2 in normal physiology and cancer

Ming Ye Feng, Rajini Rao

School of Medicine

Research output: Contribution to journal › Review article › peer-review

12 Scopus citations

Abstract

Recent studies in secretory pathway calcium ATPases (SPCA) revealed novel functions of SPCA2 in interacting with store-operated Ca²⁺ channel Orai1 and inducing Ca²⁺ influx at the cell surface. Importantly, SPCA2-mediated Ca²⁺ signaling is uncoupled from its conventional role of Ca²⁺-ATPase and independent of store-operated Ca²⁺ signaling pathway. SPCA2-induced store-independent Ca²⁺ entry (SICE) plays essential roles in many important physiological processes, while unbalanced SICE leads to enhanced cell proliferation and tumorigenesis. Finally, we have summarized the clinical implication of SICE in oral cancer prognosis and treatment. Inhibition of SICE may be a new target for the development of cancer therapeutics.

Original language	English (US)
Pages (from-to)	71-74
Number of pages	4
Journal	International Journal of Oral Science
Volume	5
Issue number	2
DOIs	https://doi.org/10.1038/ijos.2013.23
State	Published - Jun 2013

Keywords

Ca signaling
human cancers
store-independent Ca entry
store-operated Ca entry

ASJC Scopus subject areas

General Dentistry

Access to Document

10.1038/ijos.2013.23

Cite this

@article{a90b0a85ca004c849ef358ea5808544d,

title = "New insights into store-independent Ca 2+ entry: Secretory pathway calcium ATPase 2 in normal physiology and cancer",

abstract = "Recent studies in secretory pathway calcium ATPases (SPCA) revealed novel functions of SPCA2 in interacting with store-operated Ca2+ channel Orai1 and inducing Ca2+ influx at the cell surface. Importantly, SPCA2-mediated Ca2+ signaling is uncoupled from its conventional role of Ca2+-ATPase and independent of store-operated Ca2+ signaling pathway. SPCA2-induced store-independent Ca2+ entry (SICE) plays essential roles in many important physiological processes, while unbalanced SICE leads to enhanced cell proliferation and tumorigenesis. Finally, we have summarized the clinical implication of SICE in oral cancer prognosis and treatment. Inhibition of SICE may be a new target for the development of cancer therapeutics.",

keywords = "Ca signaling, human cancers, store-independent Ca entry, store-operated Ca entry",

author = "Feng, {Ming Ye} and Rajini Rao",

year = "2013",

month = jun,

doi = "10.1038/ijos.2013.23",

language = "English (US)",

volume = "5",

pages = "71--74",

journal = "International Journal of Oral Science",

issn = "1674-2818",

publisher = "Sichuan University Press",

number = "2",

}

TY - JOUR

T1 - New insights into store-independent Ca 2+ entry

T2 - Secretory pathway calcium ATPase 2 in normal physiology and cancer

AU - Feng, Ming Ye

AU - Rao, Rajini

PY - 2013/6

Y1 - 2013/6

N2 - Recent studies in secretory pathway calcium ATPases (SPCA) revealed novel functions of SPCA2 in interacting with store-operated Ca2+ channel Orai1 and inducing Ca2+ influx at the cell surface. Importantly, SPCA2-mediated Ca2+ signaling is uncoupled from its conventional role of Ca2+-ATPase and independent of store-operated Ca2+ signaling pathway. SPCA2-induced store-independent Ca2+ entry (SICE) plays essential roles in many important physiological processes, while unbalanced SICE leads to enhanced cell proliferation and tumorigenesis. Finally, we have summarized the clinical implication of SICE in oral cancer prognosis and treatment. Inhibition of SICE may be a new target for the development of cancer therapeutics.

AB - Recent studies in secretory pathway calcium ATPases (SPCA) revealed novel functions of SPCA2 in interacting with store-operated Ca2+ channel Orai1 and inducing Ca2+ influx at the cell surface. Importantly, SPCA2-mediated Ca2+ signaling is uncoupled from its conventional role of Ca2+-ATPase and independent of store-operated Ca2+ signaling pathway. SPCA2-induced store-independent Ca2+ entry (SICE) plays essential roles in many important physiological processes, while unbalanced SICE leads to enhanced cell proliferation and tumorigenesis. Finally, we have summarized the clinical implication of SICE in oral cancer prognosis and treatment. Inhibition of SICE may be a new target for the development of cancer therapeutics.

KW - Ca signaling

KW - human cancers

KW - store-independent Ca entry

KW - store-operated Ca entry

UR - http://www.scopus.com/inward/record.url?scp=84881586002&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84881586002&partnerID=8YFLogxK

U2 - 10.1038/ijos.2013.23

DO - 10.1038/ijos.2013.23

M3 - Review article

C2 - 23670239

AN - SCOPUS:84881586002

SN - 1674-2818

VL - 5

SP - 71

EP - 74

JO - International Journal of Oral Science

JF - International Journal of Oral Science

IS - 2

ER -

New insights into store-independent Ca 2+ entry: Secretory pathway calcium ATPase 2 in normal physiology and cancer

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this