New index alpha improves detection of pulmonary hypertension in comparison with other cardiac magnetic resonance indices

Sergio Moral, Leticia Fernández-Friera, Gerin Stevens, Gabriela Guzman, Ana García-Alvarez, Ajith Nair, Arturo Evangelista, Valentin Fuster, Mario J. Garcia, Javier Sanz

Research output: Contribution to journalArticle

Abstract

Background: Cardiovascular magnetic resonance (CMR) has been proposed for the evaluation of patients with pulmonary hypertension (PH). However, there is no consensus on the optimal method for PH diagnosis using CMR. Objective: To compare the diagnostic ability of multiple CMR-derived indices for the detection of PH as determined by right heart catheterization (RHC). Methods: A total of 185 patients with known or suspected chronic PH who underwent cardiac CMR and RHC in ≤ 15 days were included. PH was defined as a mean pulmonary artery (PA) pressure ≥ 25 mm Hg. Right ventricular (RV) volumes, RV ejection fraction (RVEF), PA areas, and PA average blood flow velocity were quantified with CMR. A novel index α was defined as the ratio between minimal PA area and RVEF. Results: According to the RHC, PH was present in 152 patients. All CMR-derived parameters correlated with the degree of mean PA pressure, with α having the highest correlation coefficient (r = 0.61, p <0.001). Correlations were also highest for α in the patients with pulmonary arterial hypertension (PAH; r = 0.55, p <0.001) and non-PAH subgroup (r = 0.61, p <0.001). Diagnostic accuracy for the detection of PH, based on receiver operating curve analysis, was best for α (area under the curve = 0.95). A cutoff value of 7.2 demonstrated a sensitivity of 90% and a specificity of 88%. Conclusions: An easily-obtainable and novel CMR index α that combines geometrical and functional information of the PA and the RV allows for the noninvasive diagnosis of PH with high accuracy, above other common CMR-derived parameters.

Original languageEnglish (US)
Pages (from-to)25-30
Number of pages6
JournalInternational Journal of Cardiology
Volume161
Issue number1
DOIs
StatePublished - Nov 1 2012
Externally publishedYes

Fingerprint

Pulmonary Hypertension
Magnetic Resonance Spectroscopy
Pulmonary Artery
Cardiac Catheterization
Pressure
Blood Flow Velocity
Stroke Volume
Area Under Curve

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

New index alpha improves detection of pulmonary hypertension in comparison with other cardiac magnetic resonance indices. / Moral, Sergio; Fernández-Friera, Leticia; Stevens, Gerin; Guzman, Gabriela; García-Alvarez, Ana; Nair, Ajith; Evangelista, Arturo; Fuster, Valentin; Garcia, Mario J.; Sanz, Javier.

In: International Journal of Cardiology, Vol. 161, No. 1, 01.11.2012, p. 25-30.

Research output: Contribution to journalArticle

Moral, S, Fernández-Friera, L, Stevens, G, Guzman, G, García-Alvarez, A, Nair, A, Evangelista, A, Fuster, V, Garcia, MJ & Sanz, J 2012, 'New index alpha improves detection of pulmonary hypertension in comparison with other cardiac magnetic resonance indices', International Journal of Cardiology, vol. 161, no. 1, pp. 25-30. https://doi.org/10.1016/j.ijcard.2011.04.024
Moral, Sergio ; Fernández-Friera, Leticia ; Stevens, Gerin ; Guzman, Gabriela ; García-Alvarez, Ana ; Nair, Ajith ; Evangelista, Arturo ; Fuster, Valentin ; Garcia, Mario J. ; Sanz, Javier. / New index alpha improves detection of pulmonary hypertension in comparison with other cardiac magnetic resonance indices. In: International Journal of Cardiology. 2012 ; Vol. 161, No. 1. pp. 25-30.
@article{09b7c5d56c4d4c2da22051d853928cad,
title = "New index alpha improves detection of pulmonary hypertension in comparison with other cardiac magnetic resonance indices",
abstract = "Background: Cardiovascular magnetic resonance (CMR) has been proposed for the evaluation of patients with pulmonary hypertension (PH). However, there is no consensus on the optimal method for PH diagnosis using CMR. Objective: To compare the diagnostic ability of multiple CMR-derived indices for the detection of PH as determined by right heart catheterization (RHC). Methods: A total of 185 patients with known or suspected chronic PH who underwent cardiac CMR and RHC in ≤ 15 days were included. PH was defined as a mean pulmonary artery (PA) pressure ≥ 25 mm Hg. Right ventricular (RV) volumes, RV ejection fraction (RVEF), PA areas, and PA average blood flow velocity were quantified with CMR. A novel index α was defined as the ratio between minimal PA area and RVEF. Results: According to the RHC, PH was present in 152 patients. All CMR-derived parameters correlated with the degree of mean PA pressure, with α having the highest correlation coefficient (r = 0.61, p <0.001). Correlations were also highest for α in the patients with pulmonary arterial hypertension (PAH; r = 0.55, p <0.001) and non-PAH subgroup (r = 0.61, p <0.001). Diagnostic accuracy for the detection of PH, based on receiver operating curve analysis, was best for α (area under the curve = 0.95). A cutoff value of 7.2 demonstrated a sensitivity of 90{\%} and a specificity of 88{\%}. Conclusions: An easily-obtainable and novel CMR index α that combines geometrical and functional information of the PA and the RV allows for the noninvasive diagnosis of PH with high accuracy, above other common CMR-derived parameters.",
author = "Sergio Moral and Leticia Fern{\'a}ndez-Friera and Gerin Stevens and Gabriela Guzman and Ana Garc{\'i}a-Alvarez and Ajith Nair and Arturo Evangelista and Valentin Fuster and Garcia, {Mario J.} and Javier Sanz",
year = "2012",
month = "11",
day = "1",
doi = "10.1016/j.ijcard.2011.04.024",
language = "English (US)",
volume = "161",
pages = "25--30",
journal = "International Journal of Cardiology",
issn = "0167-5273",
publisher = "Elsevier Ireland Ltd",
number = "1",

}

TY - JOUR

T1 - New index alpha improves detection of pulmonary hypertension in comparison with other cardiac magnetic resonance indices

AU - Moral, Sergio

AU - Fernández-Friera, Leticia

AU - Stevens, Gerin

AU - Guzman, Gabriela

AU - García-Alvarez, Ana

AU - Nair, Ajith

AU - Evangelista, Arturo

AU - Fuster, Valentin

AU - Garcia, Mario J.

AU - Sanz, Javier

PY - 2012/11/1

Y1 - 2012/11/1

N2 - Background: Cardiovascular magnetic resonance (CMR) has been proposed for the evaluation of patients with pulmonary hypertension (PH). However, there is no consensus on the optimal method for PH diagnosis using CMR. Objective: To compare the diagnostic ability of multiple CMR-derived indices for the detection of PH as determined by right heart catheterization (RHC). Methods: A total of 185 patients with known or suspected chronic PH who underwent cardiac CMR and RHC in ≤ 15 days were included. PH was defined as a mean pulmonary artery (PA) pressure ≥ 25 mm Hg. Right ventricular (RV) volumes, RV ejection fraction (RVEF), PA areas, and PA average blood flow velocity were quantified with CMR. A novel index α was defined as the ratio between minimal PA area and RVEF. Results: According to the RHC, PH was present in 152 patients. All CMR-derived parameters correlated with the degree of mean PA pressure, with α having the highest correlation coefficient (r = 0.61, p <0.001). Correlations were also highest for α in the patients with pulmonary arterial hypertension (PAH; r = 0.55, p <0.001) and non-PAH subgroup (r = 0.61, p <0.001). Diagnostic accuracy for the detection of PH, based on receiver operating curve analysis, was best for α (area under the curve = 0.95). A cutoff value of 7.2 demonstrated a sensitivity of 90% and a specificity of 88%. Conclusions: An easily-obtainable and novel CMR index α that combines geometrical and functional information of the PA and the RV allows for the noninvasive diagnosis of PH with high accuracy, above other common CMR-derived parameters.

AB - Background: Cardiovascular magnetic resonance (CMR) has been proposed for the evaluation of patients with pulmonary hypertension (PH). However, there is no consensus on the optimal method for PH diagnosis using CMR. Objective: To compare the diagnostic ability of multiple CMR-derived indices for the detection of PH as determined by right heart catheterization (RHC). Methods: A total of 185 patients with known or suspected chronic PH who underwent cardiac CMR and RHC in ≤ 15 days were included. PH was defined as a mean pulmonary artery (PA) pressure ≥ 25 mm Hg. Right ventricular (RV) volumes, RV ejection fraction (RVEF), PA areas, and PA average blood flow velocity were quantified with CMR. A novel index α was defined as the ratio between minimal PA area and RVEF. Results: According to the RHC, PH was present in 152 patients. All CMR-derived parameters correlated with the degree of mean PA pressure, with α having the highest correlation coefficient (r = 0.61, p <0.001). Correlations were also highest for α in the patients with pulmonary arterial hypertension (PAH; r = 0.55, p <0.001) and non-PAH subgroup (r = 0.61, p <0.001). Diagnostic accuracy for the detection of PH, based on receiver operating curve analysis, was best for α (area under the curve = 0.95). A cutoff value of 7.2 demonstrated a sensitivity of 90% and a specificity of 88%. Conclusions: An easily-obtainable and novel CMR index α that combines geometrical and functional information of the PA and the RV allows for the noninvasive diagnosis of PH with high accuracy, above other common CMR-derived parameters.

UR - http://www.scopus.com/inward/record.url?scp=84860377347&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84860377347&partnerID=8YFLogxK

U2 - 10.1016/j.ijcard.2011.04.024

DO - 10.1016/j.ijcard.2011.04.024

M3 - Article

VL - 161

SP - 25

EP - 30

JO - International Journal of Cardiology

JF - International Journal of Cardiology

SN - 0167-5273

IS - 1

ER -