New horizons for cutaneous microbiology: The role of biofilms in dermatological disease

N. Vlassova, A. Han, Jonathan Mark Zenilman, G. James, Gerald Sylvan Lazarus

Research output: Contribution to journalArticle

Abstract

Human skin is colonized by bacteria. The development of new genomic microbiological techniques has revealed that the bacterial ecology of human skin is far more complex than previously imagined and includes many fastidious or noncultivable bacterial species which are found on both normal and diseased skin. In nature, the predominant bacterial phenotype on epithelial surfaces is that of organisms organized within a biofilm. This contrasts with the widely held belief that bacteria are planktonic, i.e. free-floating single cells. Biofilms are sessile bacterial communities encased in an extracellular matrix that have a well-developed communication system and can regulate bacterial growth and metabolism, confer resistance to antimicrobials and to host inflammatory cells, and alter host metabolism. Biofilms have been observed on healthy skin and in a number of dermatological conditions, including some that were previously thought not to have an infectious aetiology. Here we review the concept of biofilms and their role in cutaneous health and disease.

Original languageEnglish (US)
Pages (from-to)751-759
Number of pages9
JournalBritish Journal of Dermatology
Volume165
Issue number4
DOIs
StatePublished - Oct 2011

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Biofilms
Microbiology
Skin
Skin Diseases
Microbiological Techniques
Bacteria
Ecology
Extracellular Matrix
Communication
Phenotype
Health
Growth

ASJC Scopus subject areas

  • Dermatology

Cite this

New horizons for cutaneous microbiology : The role of biofilms in dermatological disease. / Vlassova, N.; Han, A.; Zenilman, Jonathan Mark; James, G.; Lazarus, Gerald Sylvan.

In: British Journal of Dermatology, Vol. 165, No. 4, 10.2011, p. 751-759.

Research output: Contribution to journalArticle

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