New hepatocytes for toxicology?

Thomas Hartung, Laura Gribaldo

Research output: Contribution to journalShort surveypeer-review

3 Scopus citations


In a recent article M.G. Sacco and co-workers described the establishment of immortalized untransformed transgenic hepatocyte (MMH-GH) cell lines, obtained from a cross between the AT/cytoMet and Hsp70/hGH transgenic mice. This strategy proved to be successful because the MMH-GH showed stability in culture and sensitivity to chemical exposure. Based on these results, the MMH-GH cell lines could prove to be a valid alternative cell-based assay for use in toxicological studies.

Original languageEnglish (US)
Pages (from-to)613-615
Number of pages3
JournalTrends in Biotechnology
Issue number12
StatePublished - Dec 1 2004
Externally publishedYes

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering


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