New hemostatic dressing (FAST dressing) reduces blood loss and improves survival in a grade V liver injury model in noncoagulopathic swine

Gerard P. De Castro, Martin J. MacPhee, Ian R. Driscoll, Dawson Beall, June Hsu, Shijun Zhu, John R. Hess, Thomas M. Scalea, Grant V. Bochicchio

Research output: Contribution to journalArticle

Abstract

BACKGROUND: We performed this study to evaluate the hemostatic efficacy of the FAST Dressing in treating a grade V liver injury in noncoagulopathic swine. METHODS: Sixteen female splenectomized, noncoagulopathic swine underwent reproducible grade V liver injuries. The animals were blindly randomized to two treatment groups: (1) FAST Dressing (n = 8) or (2) IgG placebo dressing (n = 8). After 30 seconds of uncontrolled hemorrhage, dressings and manual compression were applied at 4-minute intervals. The number of dressings used, time to hemostasis, total blood loss, mean arterial pressure, blood chemistry, and total resuscitation fluid volume were monitored for 2 hours after injury. RESULTS: The mean total blood loss was 412.5 mL (SD 201.3) for the FAST Dressing group compared with 2296.6 mL (SD 1076.0) in the placebo group (p <0.001). All animals in the FAST Dressing group achieved hemostasis and survived for the duration of the experiment (2 hours) after injury, whereas none of the animals in the placebo group attained hemostasis or survived to 2 hours after injury (p <0.001). The mean time to hemostasis was 6.6 minutes (SD 2.5). A median of five dressings (mean absolute deviation 1.0, p = 0.007) was sufficient to control hemorrhage in the FAST Dressing group. CONCLUSION: The FAST Dressing reduced blood loss and improved survival compared with placebo in a noncoagulopathic, grade V liver injury swine model.

Original languageEnglish (US)
Pages (from-to)1408-1412
Number of pages5
JournalJournal of Trauma - Injury, Infection and Critical Care
Volume70
Issue number6
DOIs
StatePublished - Jun 2011
Externally publishedYes

Keywords

  • FAST Dressing
  • Fibrinogen/Thrombin Dressing
  • Hemostasis
  • Hemostatic Dressing
  • Trauma

ASJC Scopus subject areas

  • Surgery
  • Critical Care and Intensive Care Medicine

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  • Cite this

    De Castro, G. P., MacPhee, M. J., Driscoll, I. R., Beall, D., Hsu, J., Zhu, S., Hess, J. R., Scalea, T. M., & Bochicchio, G. V. (2011). New hemostatic dressing (FAST dressing) reduces blood loss and improves survival in a grade V liver injury model in noncoagulopathic swine. Journal of Trauma - Injury, Infection and Critical Care, 70(6), 1408-1412. https://doi.org/10.1097/TA.0b013e31821a1075