New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries

Understanding Society Scientific group

Research output: Contribution to journalArticle

Abstract

Reduced lung function predicts mortality and is key to the diagnosis of chronic obstructive pulmonary disease (COPD). In a genome-wide association study in 400,102 individuals of European ancestry, we define 279 lung function signals, 139 of which are new. In combination, these variants strongly predict COPD in independent populations. Furthermore, the combined effect of these variants showed generalizability across smokers and never smokers, and across ancestral groups. We highlight biological pathways, known and potential drug targets for COPD and, in phenome-wide association studies, autoimmune-related and other pleiotropic effects of lung function–associated variants. This new genetic evidence has potential to improve future preventive and therapeutic strategies for COPD.

Original languageEnglish (US)
Pages (from-to)481-493
Number of pages13
JournalNature genetics
Volume51
Issue number3
DOIs
StatePublished - Mar 1 2019

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Chronic Obstructive Pulmonary Disease
Lung
Genome-Wide Association Study
Mortality
Pharmaceutical Preparations
Population
Therapeutics

ASJC Scopus subject areas

  • Genetics

Cite this

New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries. / Understanding Society Scientific group.

In: Nature genetics, Vol. 51, No. 3, 01.03.2019, p. 481-493.

Research output: Contribution to journalArticle

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abstract = "Reduced lung function predicts mortality and is key to the diagnosis of chronic obstructive pulmonary disease (COPD). In a genome-wide association study in 400,102 individuals of European ancestry, we define 279 lung function signals, 139 of which are new. In combination, these variants strongly predict COPD in independent populations. Furthermore, the combined effect of these variants showed generalizability across smokers and never smokers, and across ancestral groups. We highlight biological pathways, known and potential drug targets for COPD and, in phenome-wide association studies, autoimmune-related and other pleiotropic effects of lung function–associated variants. This new genetic evidence has potential to improve future preventive and therapeutic strategies for COPD.",
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