New frontiers in the design and synthesis of imaging probes for PET Oncology: Current challenges and future directions

Graham Smith, Laurence Carroll, Eric O. Aboagye

Research output: Contribution to journalReview article

Abstract

Despite being developed over 30 years ago, 2-deoxy-2-[18F] fluoro-D-glucose remains the most frequently used radiotracer in PET oncology. In the last decade, interest in new and more specific radiotracers for imaging biological processes of oncologic interest has increased exponentially. This review summarizes the strategies underlying the development of those probes together with their validation and status of clinical translation; a brief summary of new radiochemistry strategies applicable to PET imaging is also included. The article finishes with a consideration of the challenges imaging scientists must overcome to bring about increased adoption of PET as a diagnostic or pharmacologic tool.

Original languageEnglish (US)
Pages (from-to)653-666
Number of pages14
JournalMolecular Imaging and Biology
Volume14
Issue number6
DOIs
StatePublished - Dec 1 2012
Externally publishedYes

Keywords

  • Positron emission tomography
  • Probe development
  • Therapy monitoring
  • [ F]FDG

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

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