New frontiers in the design and synthesis of imaging probes for PET Oncology: Current challenges and future directions

Graham Smith; Laurence Carroll; Eric O. Aboagye

doi:10.1007/s11307-012-0590-y

New frontiers in the design and synthesis of imaging probes for PET Oncology: Current challenges and future directions

Graham Smith, Laurence Carroll, Eric O. Aboagye

Research output: Contribution to journal › Review article › peer-review

29 Scopus citations

Abstract

Despite being developed over 30 years ago, 2-deoxy-2-[¹⁸F] fluoro-D-glucose remains the most frequently used radiotracer in PET oncology. In the last decade, interest in new and more specific radiotracers for imaging biological processes of oncologic interest has increased exponentially. This review summarizes the strategies underlying the development of those probes together with their validation and status of clinical translation; a brief summary of new radiochemistry strategies applicable to PET imaging is also included. The article finishes with a consideration of the challenges imaging scientists must overcome to bring about increased adoption of PET as a diagnostic or pharmacologic tool.

Original language	English (US)
Pages (from-to)	653-666
Number of pages	14
Journal	Molecular Imaging and Biology
Volume	14
Issue number	6
DOIs	https://doi.org/10.1007/s11307-012-0590-y
State	Published - Dec 1 2012
Externally published	Yes

Keywords

Positron emission tomography
Probe development
Therapy monitoring
[ F]FDG

ASJC Scopus subject areas

Oncology
Radiology Nuclear Medicine and imaging
Cancer Research

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abstract = "Despite being developed over 30 years ago, 2-deoxy-2-[18F] fluoro-D-glucose remains the most frequently used radiotracer in PET oncology. In the last decade, interest in new and more specific radiotracers for imaging biological processes of oncologic interest has increased exponentially. This review summarizes the strategies underlying the development of those probes together with their validation and status of clinical translation; a brief summary of new radiochemistry strategies applicable to PET imaging is also included. The article finishes with a consideration of the challenges imaging scientists must overcome to bring about increased adoption of PET as a diagnostic or pharmacologic tool.",

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AU - Carroll, Laurence

AU - Aboagye, Eric O.

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AB - Despite being developed over 30 years ago, 2-deoxy-2-[18F] fluoro-D-glucose remains the most frequently used radiotracer in PET oncology. In the last decade, interest in new and more specific radiotracers for imaging biological processes of oncologic interest has increased exponentially. This review summarizes the strategies underlying the development of those probes together with their validation and status of clinical translation; a brief summary of new radiochemistry strategies applicable to PET imaging is also included. The article finishes with a consideration of the challenges imaging scientists must overcome to bring about increased adoption of PET as a diagnostic or pharmacologic tool.

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KW - Probe development

KW - Therapy monitoring

KW - [ F]FDG

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New frontiers in the design and synthesis of imaging probes for PET Oncology: Current challenges and future directions

Abstract

Keywords

ASJC Scopus subject areas

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