TY - JOUR
T1 - New frontiers in fertility preservation
T2 - A hypothesis on fertility optimization in men with hypergonadotrophic hypogonadism
AU - Herati, Amin S.
AU - Kohn, Taylor P.
AU - Kassiri, Borna
N1 - Publisher Copyright:
© 2020 AME Publishing Company. All rights reserved.
PY - 2020/3/1
Y1 - 2020/3/1
N2 - Strategies exist that can mitigate the risk of causing iatrogenic infertility when men require testosterone replacement therapy (TRT). This article reviews the current medical therapies that preserve spermatogenesis when TRT is indicated. Furthermore, we highlight the re-emerging concept of hypothalamic-pituitary-gonadal (HPG) axis reset in hypergonadotrophic, hypogonadal infertile men who are planning sperm retrieval procedures. Finally, we present our hypothesis for a novel protocol to optimize hypergonadotrophic hypogonadal men before sperm extraction surgeries hormonally.
AB - Strategies exist that can mitigate the risk of causing iatrogenic infertility when men require testosterone replacement therapy (TRT). This article reviews the current medical therapies that preserve spermatogenesis when TRT is indicated. Furthermore, we highlight the re-emerging concept of hypothalamic-pituitary-gonadal (HPG) axis reset in hypergonadotrophic, hypogonadal infertile men who are planning sperm retrieval procedures. Finally, we present our hypothesis for a novel protocol to optimize hypergonadotrophic hypogonadal men before sperm extraction surgeries hormonally.
KW - Klinefelter syndrome
KW - Male fertility
KW - Non-obstructive azoospermia
KW - Testosterone hormonal therapy
KW - Testosterone therapy
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U2 - 10.21037/tau.2019.12.39
DO - 10.21037/tau.2019.12.39
M3 - Review article
C2 - 32257857
AN - SCOPUS:85081652552
VL - 9
SP - S171-S177
JO - Translational Andrology and Urology
JF - Translational Andrology and Urology
SN - 2223-4683
ER -