New frontiers in fertility preservation: A hypothesis on fertility optimization in men with hypergonadotrophic hypogonadism

Amin S. Herati, Taylor P. Kohn, Borna Kassiri

Research output: Contribution to journalReview articlepeer-review

Abstract

Strategies exist that can mitigate the risk of causing iatrogenic infertility when men require testosterone replacement therapy (TRT). This article reviews the current medical therapies that preserve spermatogenesis when TRT is indicated. Furthermore, we highlight the re-emerging concept of hypothalamic-pituitary-gonadal (HPG) axis reset in hypergonadotrophic, hypogonadal infertile men who are planning sperm retrieval procedures. Finally, we present our hypothesis for a novel protocol to optimize hypergonadotrophic hypogonadal men before sperm extraction surgeries hormonally.

Original languageEnglish (US)
Pages (from-to)S171-S177
JournalTranslational Andrology and Urology
Volume9
DOIs
StatePublished - Mar 1 2020

Keywords

  • Klinefelter syndrome
  • Male fertility
  • Non-obstructive azoospermia
  • Testosterone hormonal therapy
  • Testosterone therapy

ASJC Scopus subject areas

  • Reproductive Medicine
  • Urology

Fingerprint Dive into the research topics of 'New frontiers in fertility preservation: A hypothesis on fertility optimization in men with hypergonadotrophic hypogonadism'. Together they form a unique fingerprint.

Cite this