New fMRI postprocessing HASTE map technique to increase accuracy of the cortical BOLD activation in the visual cortex

A. B. Pinus, F. B. Mohamed, Scott Faro, J. I. Tracy, R. Koenigsberg, F. Y. Tsai

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

In functional MRI (fMRI), blood oxygenation level dependent (BOLD) imaging studies of the brain activated voxels often appear in sulci. True positive activation appears due to the presence of paramagnetic deoxyhemoglobin blood because of cortical neural activity. False positive activation may occur within non-cortical cerebrospinal fluid (CSF) spaces due to activation in vessels and CFS flow within sulci adjacent to the area performing a task. Also, true positive task-nonrelevant BOLD activation appearing in sulci away from the neuroanatomical regions associated with a specific task was assumed as false activation. Such false activations may lead to misinterpretations of fMRI maps. The currently used echo-planar imaging (EPI) techniques lack high spatial resolution to differentiate such false positive activation from true positive activation. The specific aim of this work was to develop an fMRI image postprocessing technique to identify the sulci in the EPI images using Half-Fourier Turbo-Spin Echo (HASTE) sequence. High resolution HASTE images are insensitive to susceptibility effect and have high contrast differences between areas filled with fluids and brain parenchyma. Therefore these HASTE images can be effectively used to clearly separate CSF in the sulci from other cortical brain structures where the true BOLD activation is present.

Original languageEnglish (US)
Title of host publicationAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
PublisherIEEE
Number of pages1
Volume2
ISBN (Print)0780356756
StatePublished - Dec 1 1999
Externally publishedYes
EventProceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS) - Atlanta, GA, USA
Duration: Oct 13 1999Oct 16 1999

Other

OtherProceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS)
CityAtlanta, GA, USA
Period10/13/9910/16/99

Fingerprint

Oxygenation
Blood
Chemical activation
Cerebrospinal fluid
Brain
Imaging techniques
Magnetic Resonance Imaging
Image resolution
Fluids

ASJC Scopus subject areas

  • Bioengineering

Cite this

Pinus, A. B., Mohamed, F. B., Faro, S., Tracy, J. I., Koenigsberg, R., & Tsai, F. Y. (1999). New fMRI postprocessing HASTE map technique to increase accuracy of the cortical BOLD activation in the visual cortex. In Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings (Vol. 2). IEEE.

New fMRI postprocessing HASTE map technique to increase accuracy of the cortical BOLD activation in the visual cortex. / Pinus, A. B.; Mohamed, F. B.; Faro, Scott; Tracy, J. I.; Koenigsberg, R.; Tsai, F. Y.

Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. Vol. 2 IEEE, 1999.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Pinus, AB, Mohamed, FB, Faro, S, Tracy, JI, Koenigsberg, R & Tsai, FY 1999, New fMRI postprocessing HASTE map technique to increase accuracy of the cortical BOLD activation in the visual cortex. in Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. vol. 2, IEEE, Proceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS), Atlanta, GA, USA, 10/13/99.
Pinus AB, Mohamed FB, Faro S, Tracy JI, Koenigsberg R, Tsai FY. New fMRI postprocessing HASTE map technique to increase accuracy of the cortical BOLD activation in the visual cortex. In Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. Vol. 2. IEEE. 1999
Pinus, A. B. ; Mohamed, F. B. ; Faro, Scott ; Tracy, J. I. ; Koenigsberg, R. ; Tsai, F. Y. / New fMRI postprocessing HASTE map technique to increase accuracy of the cortical BOLD activation in the visual cortex. Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. Vol. 2 IEEE, 1999.
@inproceedings{591b43ad7dcc41f192d4cbc7fad3a81e,
title = "New fMRI postprocessing HASTE map technique to increase accuracy of the cortical BOLD activation in the visual cortex",
abstract = "In functional MRI (fMRI), blood oxygenation level dependent (BOLD) imaging studies of the brain activated voxels often appear in sulci. True positive activation appears due to the presence of paramagnetic deoxyhemoglobin blood because of cortical neural activity. False positive activation may occur within non-cortical cerebrospinal fluid (CSF) spaces due to activation in vessels and CFS flow within sulci adjacent to the area performing a task. Also, true positive task-nonrelevant BOLD activation appearing in sulci away from the neuroanatomical regions associated with a specific task was assumed as false activation. Such false activations may lead to misinterpretations of fMRI maps. The currently used echo-planar imaging (EPI) techniques lack high spatial resolution to differentiate such false positive activation from true positive activation. The specific aim of this work was to develop an fMRI image postprocessing technique to identify the sulci in the EPI images using Half-Fourier Turbo-Spin Echo (HASTE) sequence. High resolution HASTE images are insensitive to susceptibility effect and have high contrast differences between areas filled with fluids and brain parenchyma. Therefore these HASTE images can be effectively used to clearly separate CSF in the sulci from other cortical brain structures where the true BOLD activation is present.",
author = "Pinus, {A. B.} and Mohamed, {F. B.} and Scott Faro and Tracy, {J. I.} and R. Koenigsberg and Tsai, {F. Y.}",
year = "1999",
month = "12",
day = "1",
language = "English (US)",
isbn = "0780356756",
volume = "2",
booktitle = "Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings",
publisher = "IEEE",

}

TY - GEN

T1 - New fMRI postprocessing HASTE map technique to increase accuracy of the cortical BOLD activation in the visual cortex

AU - Pinus, A. B.

AU - Mohamed, F. B.

AU - Faro, Scott

AU - Tracy, J. I.

AU - Koenigsberg, R.

AU - Tsai, F. Y.

PY - 1999/12/1

Y1 - 1999/12/1

N2 - In functional MRI (fMRI), blood oxygenation level dependent (BOLD) imaging studies of the brain activated voxels often appear in sulci. True positive activation appears due to the presence of paramagnetic deoxyhemoglobin blood because of cortical neural activity. False positive activation may occur within non-cortical cerebrospinal fluid (CSF) spaces due to activation in vessels and CFS flow within sulci adjacent to the area performing a task. Also, true positive task-nonrelevant BOLD activation appearing in sulci away from the neuroanatomical regions associated with a specific task was assumed as false activation. Such false activations may lead to misinterpretations of fMRI maps. The currently used echo-planar imaging (EPI) techniques lack high spatial resolution to differentiate such false positive activation from true positive activation. The specific aim of this work was to develop an fMRI image postprocessing technique to identify the sulci in the EPI images using Half-Fourier Turbo-Spin Echo (HASTE) sequence. High resolution HASTE images are insensitive to susceptibility effect and have high contrast differences between areas filled with fluids and brain parenchyma. Therefore these HASTE images can be effectively used to clearly separate CSF in the sulci from other cortical brain structures where the true BOLD activation is present.

AB - In functional MRI (fMRI), blood oxygenation level dependent (BOLD) imaging studies of the brain activated voxels often appear in sulci. True positive activation appears due to the presence of paramagnetic deoxyhemoglobin blood because of cortical neural activity. False positive activation may occur within non-cortical cerebrospinal fluid (CSF) spaces due to activation in vessels and CFS flow within sulci adjacent to the area performing a task. Also, true positive task-nonrelevant BOLD activation appearing in sulci away from the neuroanatomical regions associated with a specific task was assumed as false activation. Such false activations may lead to misinterpretations of fMRI maps. The currently used echo-planar imaging (EPI) techniques lack high spatial resolution to differentiate such false positive activation from true positive activation. The specific aim of this work was to develop an fMRI image postprocessing technique to identify the sulci in the EPI images using Half-Fourier Turbo-Spin Echo (HASTE) sequence. High resolution HASTE images are insensitive to susceptibility effect and have high contrast differences between areas filled with fluids and brain parenchyma. Therefore these HASTE images can be effectively used to clearly separate CSF in the sulci from other cortical brain structures where the true BOLD activation is present.

UR - http://www.scopus.com/inward/record.url?scp=0033323839&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033323839&partnerID=8YFLogxK

M3 - Conference contribution

AN - SCOPUS:0033323839

SN - 0780356756

VL - 2

BT - Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings

PB - IEEE

ER -