New evidence to reconcile in vitro and epidemiologic data on the possible role of heroin on CD4+ decline among HIV-infected injecting drug users

Anneke Krol, Colin Flynn, David Vlahov, Frank Miedema, Roel A. Coutinho, Erik J.C. Van Ameijden

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Long-term effects of drug type and other drug use related risk factors on CD4+ cell decline were assessed in 224 HIV-infected injecting drug users (IDUs) from Baltimore (ALIVE), USA, and 63 IDUs from Amsterdam, The Netherlands. Higher frequencies of borrowing used injection equipment since 1980 resulted in a higher CD4+ count already present before seroconversion (P=0.049). Use of mainly heroin in the seroconversion interval resulted in a sharper CD4+ decline until the first 6 months after seroconversion (P=0.004), but CD4+ values converged later on. This finding might reconcile earlier discordant epidemiological and laboratory study results regarding the possible effects of heroin. Copyright (C) 1999 Elsevier Science Ireland Ltd.

    Original languageEnglish (US)
    Pages (from-to)145-154
    Number of pages10
    JournalDrug and alcohol dependence
    Volume54
    Issue number2
    DOIs
    StatePublished - Apr 1 1999

    Keywords

    • CD4+ lymphocyte decline
    • Drug users
    • HIV
    • Heroin
    • Substance abuse

    ASJC Scopus subject areas

    • Toxicology
    • Pharmacology
    • Psychiatry and Mental health
    • Pharmacology (medical)

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