NEW ENZYME IMMUNOASSAYS FOR MEASUREMENT OF INFLUENZA A/VICTORIA/3/75 VIRUS IN NASAL WASHES

RichardA Berg, StephenI Rennard, BrianR Murphy, Robert H Yolken, Raphael Dolin, StephenE Straus

Research output: Contribution to journalArticle

Abstract

Nasopharyngeal (NP) washes from 12 patients experimentally infected with influenza A/Victoria/3/75 wild-type virus were tested in 2 newly developed enzyme-immunoassay (EIA) systems. Results were compared with infectivity titres of the NP wash specimens in rhesus monkey kidney-tissue culture. EIA detected A/Victoria/3/75 hæmagglutinin antigen for more days than did culture. EIA is also rapid and easy to do in large numbers; hence it may have advantages over culture methods for the diagnosis of influenza infections and the investigation of influenza epidemiology.

Original languageEnglish (US)
Pages (from-to)851-853
Number of pages3
JournalThe Lancet
Volume315
Issue number8173
DOIs
StatePublished - Apr 19 1980

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Immunoenzyme Techniques
Nose
Human Influenza
Victoria
Viruses
Macaca mulatta
Epidemiology
Kidney
Antigens
Infection

ASJC Scopus subject areas

  • Medicine(all)

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NEW ENZYME IMMUNOASSAYS FOR MEASUREMENT OF INFLUENZA A/VICTORIA/3/75 VIRUS IN NASAL WASHES. / Berg, RichardA; Rennard, StephenI; Murphy, BrianR; Yolken, Robert H; Dolin, Raphael; Straus, StephenE.

In: The Lancet, Vol. 315, No. 8173, 19.04.1980, p. 851-853.

Research output: Contribution to journalArticle

Berg, RichardA ; Rennard, StephenI ; Murphy, BrianR ; Yolken, Robert H ; Dolin, Raphael ; Straus, StephenE. / NEW ENZYME IMMUNOASSAYS FOR MEASUREMENT OF INFLUENZA A/VICTORIA/3/75 VIRUS IN NASAL WASHES. In: The Lancet. 1980 ; Vol. 315, No. 8173. pp. 851-853.
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