NEW ENZYME IMMUNOASSAYS FOR MEASUREMENT OF INFLUENZA A/VICTORIA/3/75 VIRUS IN NASAL WASHES

Richard A. Berg; Stephen I. Rennard; Brian R. Murphy; Robert H. Yolken; Raphael Dolin; Stephen E. Straus

doi:10.1016/S0140-6736(80)91356-2

NEW ENZYME IMMUNOASSAYS FOR MEASUREMENT OF INFLUENZA A/VICTORIA/3/75 VIRUS IN NASAL WASHES

Richard A. Berg, Stephen I. Rennard, Brian R. Murphy, Robert H. Yolken, Raphael Dolin, Stephen E. Straus

School of Medicine

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

Nasopharyngeal (NP) washes from 12 patients experimentally infected with influenza A/Victoria/3/75 wild-type virus were tested in 2 newly developed enzyme-immunoassay (EIA) systems. Results were compared with infectivity titres of the NP wash specimens in rhesus monkey kidney-tissue culture. EIA detected A/Victoria/3/75 hæmagglutinin antigen for more days than did culture. EIA is also rapid and easy to do in large numbers; hence it may have advantages over culture methods for the diagnosis of influenza infections and the investigation of influenza epidemiology.

Original language	English (US)
Pages (from-to)	851-853
Number of pages	3
Journal	The Lancet
Volume	315
Issue number	8173
DOIs	https://doi.org/10.1016/S0140-6736(80)91356-2
State	Published - Apr 19 1980

ASJC Scopus subject areas

General Medicine

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title = "NEW ENZYME IMMUNOASSAYS FOR MEASUREMENT OF INFLUENZA A/VICTORIA/3/75 VIRUS IN NASAL WASHES",

abstract = "Nasopharyngeal (NP) washes from 12 patients experimentally infected with influenza A/Victoria/3/75 wild-type virus were tested in 2 newly developed enzyme-immunoassay (EIA) systems. Results were compared with infectivity titres of the NP wash specimens in rhesus monkey kidney-tissue culture. EIA detected A/Victoria/3/75 h{\ae}magglutinin antigen for more days than did culture. EIA is also rapid and easy to do in large numbers; hence it may have advantages over culture methods for the diagnosis of influenza infections and the investigation of influenza epidemiology.",

author = "Berg, {Richard A.} and Rennard, {Stephen I.} and Murphy, {Brian R.} and Yolken, {Robert H.} and Raphael Dolin and Straus, {Stephen E.}",

year = "1980",

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T1 - NEW ENZYME IMMUNOASSAYS FOR MEASUREMENT OF INFLUENZA A/VICTORIA/3/75 VIRUS IN NASAL WASHES

AU - Berg, Richard A.

AU - Rennard, Stephen I.

AU - Murphy, Brian R.

AU - Yolken, Robert H.

AU - Dolin, Raphael

AU - Straus, Stephen E.

PY - 1980/4/19

Y1 - 1980/4/19

N2 - Nasopharyngeal (NP) washes from 12 patients experimentally infected with influenza A/Victoria/3/75 wild-type virus were tested in 2 newly developed enzyme-immunoassay (EIA) systems. Results were compared with infectivity titres of the NP wash specimens in rhesus monkey kidney-tissue culture. EIA detected A/Victoria/3/75 hæmagglutinin antigen for more days than did culture. EIA is also rapid and easy to do in large numbers; hence it may have advantages over culture methods for the diagnosis of influenza infections and the investigation of influenza epidemiology.

AB - Nasopharyngeal (NP) washes from 12 patients experimentally infected with influenza A/Victoria/3/75 wild-type virus were tested in 2 newly developed enzyme-immunoassay (EIA) systems. Results were compared with infectivity titres of the NP wash specimens in rhesus monkey kidney-tissue culture. EIA detected A/Victoria/3/75 hæmagglutinin antigen for more days than did culture. EIA is also rapid and easy to do in large numbers; hence it may have advantages over culture methods for the diagnosis of influenza infections and the investigation of influenza epidemiology.

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NEW ENZYME IMMUNOASSAYS FOR MEASUREMENT OF INFLUENZA A/VICTORIA/3/75 VIRUS IN NASAL WASHES

Abstract

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