New drugs and novel targets for treatment of invasive fungal infections in patients with cancer

Christine C. Chiou; Andreas H. Groll; Thomas J. Walsh

doi:10.1634/theoncologist.5-2-120

New drugs and novel targets for treatment of invasive fungal infections in patients with cancer

Christine C. Chiou, Andreas H. Groll, Thomas J. Walsh

Research output: Contribution to journal › Article › peer-review

108 Scopus citations

Abstract

Invasive fungal infections have emerged as important causes of morbidity and mortality in profoundly immuno-compromised patients with cancer. Current treatment strategies for these infections are limited by antifungal resistance, toxicity, drug interactions, and expense. In order to overcome these limitations, new antifungal compounds are being developed, which may improve our therapeutic armamentarium for prevention and treatment of invasive mycoses in high-risk patients with neoplastic diseases.

Original language	English (US)
Pages (from-to)	120-135
Number of pages	16
Journal	Oncologist
Volume	5
Issue number	2
DOIs	https://doi.org/10.1634/theoncologist.5-2-120
State	Published - 2000
Externally published	Yes

Keywords

Echinocondins
Posaconazole
Ravuconazole
Triazoles
Voriconazole

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1634/theoncologist.5-2-120

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abstract = "Invasive fungal infections have emerged as important causes of morbidity and mortality in profoundly immuno-compromised patients with cancer. Current treatment strategies for these infections are limited by antifungal resistance, toxicity, drug interactions, and expense. In order to overcome these limitations, new antifungal compounds are being developed, which may improve our therapeutic armamentarium for prevention and treatment of invasive mycoses in high-risk patients with neoplastic diseases.",

keywords = "Echinocondins, Posaconazole, Ravuconazole, Triazoles, Voriconazole",

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AU - Groll, Andreas H.

AU - Walsh, Thomas J.

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AB - Invasive fungal infections have emerged as important causes of morbidity and mortality in profoundly immuno-compromised patients with cancer. Current treatment strategies for these infections are limited by antifungal resistance, toxicity, drug interactions, and expense. In order to overcome these limitations, new antifungal compounds are being developed, which may improve our therapeutic armamentarium for prevention and treatment of invasive mycoses in high-risk patients with neoplastic diseases.

KW - Echinocondins

KW - Posaconazole

KW - Ravuconazole

KW - Triazoles

KW - Voriconazole

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New drugs and novel targets for treatment of invasive fungal infections in patients with cancer

Abstract

Keywords

ASJC Scopus subject areas

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