New Directions in the Delivery of Drugs and Other Substances to the Central Nervous System

Yvette Madrid, Laura Feigenbaum Langer, Henry Brem, Robert Langer

Research output: Contribution to journalArticlepeer-review

Abstract

The development of techniques aimed at the successful delivery of drugs to the CNS has most recently focused directly on the problem of penetrating the blood–brain barrier (BBB). Three main approaches have been used in this chapter: modifying the barrier, modifying the agents, and circumventing the barrier. The best method for CNS delivery should be noninvasive and allow the drug to be localized to specific parts of the brain. It should be applicable for a broad range of compounds, and it should be appropriate for both long-term and short-term use. The chapter contains a partial summary of the technologies available and some of their advantages and disadvantages. In the next few decades, there may be an increased need for the effective delivery of therapeutic agents to the CNS. The research aims to meet these intensifying demands by improving the present technology, combining current drug delivery methods, or developing altogether new methods.

Original languageEnglish (US)
Pages (from-to)299-324
Number of pages26
JournalAdvances in Pharmacology
Volume22
Issue numberC
DOIs
StatePublished - Jan 1 1991

ASJC Scopus subject areas

  • Pharmacology

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