New Devices for Imaging in Nuclear Medicine

Roberto Pani, Rosanna Pellegrini, Maria Nerina Cinti, Carlo Trotta, Paolo Bennati, Margherita Betti, Giuseppe De Vincentis, Francesco Cusanno, Franco Garibaldi, Stefano Ridolfi, Stan Majewsky, Benjamin M.W. Tsui

Research output: Contribution to journalArticle

Abstract

Pinhole gamma camera imaging offers the ability to obtain high resolution images from single gamma ray emitting radiotracers playing a reasonable tradeoff between very small field of view (FoV) and sensitivity. On the other hand the total spatial resolution of a pinhole imaging device is predominantly affected by the detector intrinsic spatial resolution for reduced magnification factors. To design very compact pinhole SPET scanners with very high intrinsic spatial resolution, authors investigated a miniature gamma camera based on the newly developed Hamamatsu H8500 flat panel photomultiplier. The PSPMT was coupled to the following scintillation arrays: CsI(Tl) array with 0.2-mm, 1-mm, 1.4-mm pixel size and NaI (Tl) with 1-mm pixel size. The imaging performances were evaluated by 57Co spot and flood irradiations. NaI(Tl) array shows a better pixel identification for 1 mm pixel size, proving to be a good candidate to make a large area photodetector based on multi PSPMTs closely packed. Although CsI(Tl) array had the smallest pixel size, the low light output limited the best intrinsic spatial resolution to about 0.5 mm.

Original languageEnglish (US)
Pages (from-to)121-128
Number of pages8
JournalCancer Biotherapy and Radiopharmaceuticals
Volume19
Issue number1
DOIs
StatePublished - Mar 26 2004

Keywords

  • Gamma camera
  • High resolution imaging
  • Imaging
  • Imaging probe

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Pharmacology
  • Cancer Research

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  • Cite this

    Pani, R., Pellegrini, R., Cinti, M. N., Trotta, C., Bennati, P., Betti, M., De Vincentis, G., Cusanno, F., Garibaldi, F., Ridolfi, S., Majewsky, S., & Tsui, B. M. W. (2004). New Devices for Imaging in Nuclear Medicine. Cancer Biotherapy and Radiopharmaceuticals, 19(1), 121-128. https://doi.org/10.1089/108497804773391766