New concept in stroke diagnosis

E. Dabiri Ali, Richard Leigh, Ghassan S. Kassab

Research output: Contribution to journalArticle

Abstract

Stroke is a life-threatening event that is expected to more than double over the next 40 years. Approximately 85% of strokes are ischemic in nature and result from thromboembolic occlusion of a major cerebral artery or its branches. One of the diagnostic methods for detection of the cerebral ischemia is the gadolinium-enhanced MRI imaging. It is mainly used in patients to detect brain tissue damaged by an ischemic stroke and brain hemorrhage. These techniques are expensive, require sophisticated machines and are time consuming. A recent study in acute stroke patients showed gadolinium leakage into ocular structures (GLOS) during MRI imaging with gadolinium administration. The results indicate that at 2 hours after administration of the contrast agent, GLOS was more common in the aqueous chamber alone, compared to the vitreous chamber with increasing amount in 24 hours after the administration of the contrast agent. This could be due to disruption of blood-ocular barrier similar to the disruption of blood-brain barrier in acute stroke. A new approach to diagnosis of acute stroke and transient ischemic attack (TIA) is through the detection of sodium fluorescein contrast agent in the eye by i.v. injection. The agent is safe and is used routinely in eye fluorescein angiography. Fluorescein fluorescence occurs at the visible wavelengths and can be detected by fluorescein angiography camera. The fluorescein angiography camera prices are affordable for any medical clinic. The innovation of this method is to leverage the eye as the window to the brain. The method can potentially detect acute stroke and TIA without MRI. This can have a far-reaching impact on the healthcare system. The eventual feature of the device will be portability and simplicity of operation that can be used by a medical technician in medical office, emergency outfits and even in ambulances given the portability.

Original languageEnglish (US)
Pages (from-to)225-233
Number of pages9
JournalMCB Molecular and Cellular Biomechanics
Volume16
Issue number4
DOIs
StatePublished - Jan 1 2019

Fingerprint

Stroke
Gadolinium
Fluorescein Angiography
Contrast Media
Transient Ischemic Attack
Fluorescein
Ambulances
Cerebral Arteries
Intracranial Hemorrhages
Brain
Brain Ischemia
Blood-Brain Barrier
Emergencies
Fluorescence
Delivery of Health Care
Equipment and Supplies
Injections

Keywords

  • Acute Ischemia
  • Diagnosis
  • Eye
  • Fluorescein angiography
  • MRI Imaging
  • Stroke

ASJC Scopus subject areas

  • Biophysics
  • Molecular Medicine
  • Molecular Biology
  • Cell Biology

Cite this

New concept in stroke diagnosis. / Ali, E. Dabiri; Leigh, Richard; Kassab, Ghassan S.

In: MCB Molecular and Cellular Biomechanics, Vol. 16, No. 4, 01.01.2019, p. 225-233.

Research output: Contribution to journalArticle

Ali, E. Dabiri ; Leigh, Richard ; Kassab, Ghassan S. / New concept in stroke diagnosis. In: MCB Molecular and Cellular Biomechanics. 2019 ; Vol. 16, No. 4. pp. 225-233.
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