New cholera vaccines

Jan Holmgren; John Clemens; David A. Sack; Ann Mari Svennerholm

doi:10.1016/0264-410X(89)90042-X

New cholera vaccines

Jan Holmgren, John Clemens, David A. Sack, Ann Mari Svennerholm

Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

Development of improved cholera vaccines has progressed rapidly in recent years. An oral killed vaccine, designed to evoke antibacterial as well as antitoxic intestinal immunity, has proved to be completely safe and to protect against cholera for at least 3 years. This vaccine also confers substantial though more short-lasting immunity against diarrhoea caused by enterotoxigenic Escherichia coli. Significant progress has also been made towards developing a live attenuated cholera vaccine using recombinant DNA techniques. The advent of effective oral cholera vaccines gives hope for improved control of cholera in the Third World.

Original language	English (US)
Pages (from-to)	94-96
Number of pages	3
Journal	Vaccine
Volume	7
Issue number	2
DOIs	https://doi.org/10.1016/0264-410X(89)90042-X
State	Published - Apr 1989

ASJC Scopus subject areas

Molecular Medicine
General Immunology and Microbiology
General Veterinary
Public Health, Environmental and Occupational Health
Infectious Diseases

Access to Document

10.1016/0264-410X(89)90042-X

Cite this

@article{2b5faec2fa8145c1a585ee5abde37a44,

title = "New cholera vaccines",

abstract = "Development of improved cholera vaccines has progressed rapidly in recent years. An oral killed vaccine, designed to evoke antibacterial as well as antitoxic intestinal immunity, has proved to be completely safe and to protect against cholera for at least 3 years. This vaccine also confers substantial though more short-lasting immunity against diarrhoea caused by enterotoxigenic Escherichia coli. Significant progress has also been made towards developing a live attenuated cholera vaccine using recombinant DNA techniques. The advent of effective oral cholera vaccines gives hope for improved control of cholera in the Third World.",

author = "Jan Holmgren and John Clemens and Sack, {David A.} and Svennerholm, {Ann Mari}",

year = "1989",

month = apr,

doi = "10.1016/0264-410X(89)90042-X",

language = "English (US)",

volume = "7",

pages = "94--96",

journal = "Vaccine",

issn = "0264-410X",

publisher = "Elsevier BV",

number = "2",

}

TY - JOUR

T1 - New cholera vaccines

AU - Holmgren, Jan

AU - Clemens, John

AU - Sack, David A.

AU - Svennerholm, Ann Mari

PY - 1989/4

Y1 - 1989/4

N2 - Development of improved cholera vaccines has progressed rapidly in recent years. An oral killed vaccine, designed to evoke antibacterial as well as antitoxic intestinal immunity, has proved to be completely safe and to protect against cholera for at least 3 years. This vaccine also confers substantial though more short-lasting immunity against diarrhoea caused by enterotoxigenic Escherichia coli. Significant progress has also been made towards developing a live attenuated cholera vaccine using recombinant DNA techniques. The advent of effective oral cholera vaccines gives hope for improved control of cholera in the Third World.

AB - Development of improved cholera vaccines has progressed rapidly in recent years. An oral killed vaccine, designed to evoke antibacterial as well as antitoxic intestinal immunity, has proved to be completely safe and to protect against cholera for at least 3 years. This vaccine also confers substantial though more short-lasting immunity against diarrhoea caused by enterotoxigenic Escherichia coli. Significant progress has also been made towards developing a live attenuated cholera vaccine using recombinant DNA techniques. The advent of effective oral cholera vaccines gives hope for improved control of cholera in the Third World.

UR - http://www.scopus.com/inward/record.url?scp=0024515731&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024515731&partnerID=8YFLogxK

U2 - 10.1016/0264-410X(89)90042-X

DO - 10.1016/0264-410X(89)90042-X

M3 - Article

C2 - 2665353

AN - SCOPUS:0024515731

SN - 0264-410X

VL - 7

SP - 94

EP - 96

JO - Vaccine

JF - Vaccine

IS - 2

ER -

New cholera vaccines

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this