New B7 Family Members with Positive and Negative Costimulatory Function

Cecilia Rietz, Lieping Chen

Research output: Contribution to journalArticlepeer-review

Abstract

The B7 family of T-cell costimulatory molecules has expanded considerably in recent years. Among the new costimulatory molecules discovered are inhibitory and activating pathways. Both ligands and receptors often have multiple binding partners, adding to the complexity of T-cell regulation. Some B7 molecules also exhibit reverse signaling, affecting activation of both antigen-presenting cells and T cells. An increased understanding of these pathways of T-cell regulation results in promising new therapeutics because T-cell interference can be better targeted to specific states of activation or location. This will decrease side-effects such as systemic immunosuppression and increase efficiency. Targeting B7 molecular pathways for either inhibiting or increasing cell-mediated immunity has so far shown promising results in models of autoimmunity, transplant rejection and tumor immunotherapy.

Original languageEnglish (US)
Pages (from-to)8-14
Number of pages7
JournalAmerican Journal of Transplantation
Volume4
Issue number1
DOIs
StatePublished - Jan 2004
Externally publishedYes

Keywords

  • B7 molecules
  • Costimulation
  • T cells

ASJC Scopus subject areas

  • Immunology

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