Plasminogen activators are increased in psoriasis, wound repair, and squamous cell carcinoma. Psoriasis has increased amounts of t-PA; t-PA is produced in the epidermis and seems to be related to epithelial activation. There is abundant plasminogen in psoriatic epidermis, and plasmin can activate complement. Therefore, it is possible that one of the proinflammatory events in psoriasis is the induction of synthesis of t-PA, which cleaves complement and induces the accumulation of inflammatory cells.
|Original language||English (US)|
|Number of pages||3|
|Journal||Seminars in Dermatology|
|Issue number||4 SUPPL. 1|
|State||Published - Jan 1 1992|
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