New aspects of pathogenesis of psoriasis

G. S. Lazarus, H. H. Roenigk

Research output: Contribution to journalArticle

Abstract

Plasminogen activators are increased in psoriasis, wound repair, and squamous cell carcinoma. Psoriasis has increased amounts of t-PA; t-PA is produced in the epidermis and seems to be related to epithelial activation. There is abundant plasminogen in psoriatic epidermis, and plasmin can activate complement. Therefore, it is possible that one of the proinflammatory events in psoriasis is the induction of synthesis of t-PA, which cleaves complement and induces the accumulation of inflammatory cells.

Original languageEnglish (US)
Pages (from-to)2-4
Number of pages3
JournalSeminars in Dermatology
Volume11
Issue number4 SUPPL. 1
StatePublished - Jan 1 1992
Externally publishedYes

ASJC Scopus subject areas

  • Dermatology

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  • Cite this

    Lazarus, G. S., & Roenigk, H. H. (1992). New aspects of pathogenesis of psoriasis. Seminars in Dermatology, 11(4 SUPPL. 1), 2-4.