New approaches in immunotherapy: Allergen vaccination with immunostimulatory DNA

Research output: Contribution to journalReview articlepeer-review

Abstract

Despite its success, conventional immunotherapy is saddled with a number of encumbrances. An allergenic vaccine that could reduce allergenicity, maintain immunogenicity, and be given in a few doses would have important therapeutic implications, as millions of patients with poorly controlled allergic rhinitis and asthma would be candidates for such a form of immunomodulation. This article addresses a specific adjuvant approach to immunotherapy in which highly active immunostimulatory phosphorothioate oligodeoxyribonucleotide moieties are linked to the principal allergenic moiety of a relevant aeroallergen.

Original languageEnglish (US)
Pages (from-to)569-581
Number of pages13
JournalImmunology and Allergy Clinics of North America
Volume24
Issue number4 SPEC. ISS.
DOIs
StatePublished - Nov 2004

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Fingerprint Dive into the research topics of 'New approaches in immunotherapy: Allergen vaccination with immunostimulatory DNA'. Together they form a unique fingerprint.

Cite this