TY - JOUR
T1 - New approaches in immunotherapy
T2 - Allergen vaccination with immunostimulatory DNA
AU - Creticos, Peter Socrates
AU - Chen, Yi Hsing
AU - Schroeder, John T.
PY - 2004/11
Y1 - 2004/11
N2 - Despite its success, conventional immunotherapy is saddled with a number of encumbrances. An allergenic vaccine that could reduce allergenicity, maintain immunogenicity, and be given in a few doses would have important therapeutic implications, as millions of patients with poorly controlled allergic rhinitis and asthma would be candidates for such a form of immunomodulation. This article addresses a specific adjuvant approach to immunotherapy in which highly active immunostimulatory phosphorothioate oligodeoxyribonucleotide moieties are linked to the principal allergenic moiety of a relevant aeroallergen.
AB - Despite its success, conventional immunotherapy is saddled with a number of encumbrances. An allergenic vaccine that could reduce allergenicity, maintain immunogenicity, and be given in a few doses would have important therapeutic implications, as millions of patients with poorly controlled allergic rhinitis and asthma would be candidates for such a form of immunomodulation. This article addresses a specific adjuvant approach to immunotherapy in which highly active immunostimulatory phosphorothioate oligodeoxyribonucleotide moieties are linked to the principal allergenic moiety of a relevant aeroallergen.
UR - http://www.scopus.com/inward/record.url?scp=5044237403&partnerID=8YFLogxK
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U2 - 10.1016/j.iac.2004.06.012
DO - 10.1016/j.iac.2004.06.012
M3 - Review article
C2 - 15474859
AN - SCOPUS:5044237403
SN - 0889-8561
VL - 24
SP - 569
EP - 581
JO - Immunology and Allergy Clinics of North America
JF - Immunology and Allergy Clinics of North America
IS - 4 SPEC. ISS.
ER -