Abstract
Because the brainstem has little functional redundancy, diffuse lesions have been regarded as inoperable. To determine whether local drug therapy can prolong survival in a rodent model of a tumor in such eloquent tissue, lethal doses of F98 and 9L tumor cells were injected into the brainstems of Fischer 344 rats. Five days after inoculations, 0.5 mg/ml solutions of carboplatin were infused at 1 μl/h for 7 days. Compared to control groups that survived 13-17 days with F98 tumors and 22-23 days with 9L tumors, animals locally infused with 0.1 mg of carboplatin survived 27-30 days (Prob > Chi Sq = 0.0003), and 32 days (Prob > Chi Sq = 0.01), respectively. Measurements of tissue platinum levels at autopsy suggested that infusions distributed pharmacologically relevant levels of carboplatin through a volume of tissue at least 0.5 cm in diameter. The results suggest that chronic low-flow infusions provide a promising approach to therapy for CNS lesions in tissues considered to be inoperable.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 151-158 |
| Number of pages | 8 |
| Journal | Journal of Neuro-Oncology |
| Volume | 60 |
| Issue number | 2 |
| DOIs | |
| State | Published - Nov 1 2002 |
Fingerprint
Keywords
- Brainstem tumors
- Carboplatin
- CNS cancer
- Intracranial drug delivery
- Intraparenchymal therapy
ASJC Scopus subject areas
- Clinical Neurology
- Cancer Research
- Oncology
- Neuroscience(all)
Cite this
New approach to tumor therapy for inoperable areas of the brain chronic intraparenchymal drug delivery. / Solomon, Benjamin; Wu, Q.; Tyler, Betty Mae; Sukay, L.; Raychaudhuri, R.; DiMeco, F.; Clatterbuck, R. E.; Olivi, Alessandro; Guarnieri, M.
In: Journal of Neuro-Oncology, Vol. 60, No. 2, 01.11.2002, p. 151-158.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - New approach to tumor therapy for inoperable areas of the brain chronic intraparenchymal drug delivery
AU - Solomon, Benjamin
AU - Wu, Q.
AU - Tyler, Betty Mae
AU - Sukay, L.
AU - Raychaudhuri, R.
AU - DiMeco, F.
AU - Clatterbuck, R. E.
AU - Olivi, Alessandro
AU - Guarnieri, M.
PY - 2002/11/1
Y1 - 2002/11/1
N2 - Because the brainstem has little functional redundancy, diffuse lesions have been regarded as inoperable. To determine whether local drug therapy can prolong survival in a rodent model of a tumor in such eloquent tissue, lethal doses of F98 and 9L tumor cells were injected into the brainstems of Fischer 344 rats. Five days after inoculations, 0.5 mg/ml solutions of carboplatin were infused at 1 μl/h for 7 days. Compared to control groups that survived 13-17 days with F98 tumors and 22-23 days with 9L tumors, animals locally infused with 0.1 mg of carboplatin survived 27-30 days (Prob > Chi Sq = 0.0003), and 32 days (Prob > Chi Sq = 0.01), respectively. Measurements of tissue platinum levels at autopsy suggested that infusions distributed pharmacologically relevant levels of carboplatin through a volume of tissue at least 0.5 cm in diameter. The results suggest that chronic low-flow infusions provide a promising approach to therapy for CNS lesions in tissues considered to be inoperable.
AB - Because the brainstem has little functional redundancy, diffuse lesions have been regarded as inoperable. To determine whether local drug therapy can prolong survival in a rodent model of a tumor in such eloquent tissue, lethal doses of F98 and 9L tumor cells were injected into the brainstems of Fischer 344 rats. Five days after inoculations, 0.5 mg/ml solutions of carboplatin were infused at 1 μl/h for 7 days. Compared to control groups that survived 13-17 days with F98 tumors and 22-23 days with 9L tumors, animals locally infused with 0.1 mg of carboplatin survived 27-30 days (Prob > Chi Sq = 0.0003), and 32 days (Prob > Chi Sq = 0.01), respectively. Measurements of tissue platinum levels at autopsy suggested that infusions distributed pharmacologically relevant levels of carboplatin through a volume of tissue at least 0.5 cm in diameter. The results suggest that chronic low-flow infusions provide a promising approach to therapy for CNS lesions in tissues considered to be inoperable.
KW - Brainstem tumors
KW - Carboplatin
KW - CNS cancer
KW - Intracranial drug delivery
KW - Intraparenchymal therapy
UR - http://www.scopus.com/inward/record.url?scp=0036842689&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036842689&partnerID=8YFLogxK
U2 - 10.1023/A:1020626419269
DO - 10.1023/A:1020626419269
M3 - Article
VL - 60
SP - 151
EP - 158
JO - Journal of Neuro-Oncology
JF - Journal of Neuro-Oncology
SN - 0167-594X
IS - 2
ER -