Abstract
Because the brainstem has little functional redundancy, diffuse lesions have been regarded as inoperable. To determine whether local drug therapy can prolong survival in a rodent model of a tumor in such eloquent tissue, lethal doses of F98 and 9L tumor cells were injected into the brainstems of Fischer 344 rats. Five days after inoculations, 0.5 mg/ml solutions of carboplatin were infused at 1 μl/h for 7 days. Compared to control groups that survived 13-17 days with F98 tumors and 22-23 days with 9L tumors, animals locally infused with 0.1 mg of carboplatin survived 27-30 days (Prob > Chi Sq = 0.0003), and 32 days (Prob > Chi Sq = 0.01), respectively. Measurements of tissue platinum levels at autopsy suggested that infusions distributed pharmacologically relevant levels of carboplatin through a volume of tissue at least 0.5 cm in diameter. The results suggest that chronic low-flow infusions provide a promising approach to therapy for CNS lesions in tissues considered to be inoperable.
Original language | English (US) |
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Pages (from-to) | 151-158 |
Number of pages | 8 |
Journal | Journal of neuro-oncology |
Volume | 60 |
Issue number | 2 |
DOIs | |
State | Published - Nov 1 2002 |
Keywords
- Brainstem tumors
- CNS cancer
- Carboplatin
- Intracranial drug delivery
- Intraparenchymal therapy
ASJC Scopus subject areas
- Oncology
- Neurology
- Clinical Neurology
- Cancer Research