TY - JOUR
T1 - New antibacterial drugs for the treatment of mycobacterial disease in man
AU - Mitchison, D. A.
AU - Ellard, G. A.
AU - Grosset, J.
PY - 1988
Y1 - 1988
N2 - New chemotherapeutic drugs are needed for the treatment of mycobacterial infections to expand the number of available drugs in the face of increasing drug-resistance, to shorten the period of treatment, to allow effective treatment of Mycobacterium avium-intracellulare-scrofulaceum (MAIS) complex infections and, of greatest importance for tuberculosis, to facilitate fully supervised, widely intermittent regimes. Several new rifamycin derivatives are being explored and appear likely to achieve many of these aims. The fluorinated quinolones are the most promising new drugs for the treatment of leprosy. However, the most active quinolones are only just effective in tuberculosis at current dose levels. The β-lactam group and inhibitors of dihydrofolate reductase are only at the stage of in vitro study
AB - New chemotherapeutic drugs are needed for the treatment of mycobacterial infections to expand the number of available drugs in the face of increasing drug-resistance, to shorten the period of treatment, to allow effective treatment of Mycobacterium avium-intracellulare-scrofulaceum (MAIS) complex infections and, of greatest importance for tuberculosis, to facilitate fully supervised, widely intermittent regimes. Several new rifamycin derivatives are being explored and appear likely to achieve many of these aims. The fluorinated quinolones are the most promising new drugs for the treatment of leprosy. However, the most active quinolones are only just effective in tuberculosis at current dose levels. The β-lactam group and inhibitors of dihydrofolate reductase are only at the stage of in vitro study
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U2 - 10.1093/oxfordjournals.bmb.a072281
DO - 10.1093/oxfordjournals.bmb.a072281
M3 - Article
C2 - 3076819
AN - SCOPUS:0023942279
SN - 0007-1420
VL - 44
SP - 757
EP - 774
JO - British Medical Bulletin
JF - British Medical Bulletin
IS - 3
ER -