New advances in the pathophysiology of intestinal ion transport and barrier function in diarrhea and the impact on therapy

Kazi Mirajul Hoque, Subhra Chakraborty, Irshad Ali Sheikh, Owen M. Woodward

Research output: Contribution to journalReview article

Abstract

Diarrhea remains a continuous threat to human health worldwide. Scaling up the best practices for diarrhea prevention requires improved therapies. Diarrhea results from dysregulation of normal intestinal ion transport functions. Host-microbe contact is a key determinant of this response. Underlying mechanisms in the disease state are regulated by intracellular signals that modulate the activity of individual transport proteins responsible for ion transport and barrier function. Similarly, virulence factors of pathogens and their complex interaction with the host has shed light on the mechanism of enteric infection. Great advances in our understanding of the pathophysiologic mechanisms of epithelial transport, and host-microbe interaction have been made in recent years. Application of these new advances may represent strategies to decrease pathogen attachment, enhance intestinal cation absorption, decrease anion secretion and repair barrier function. This review highlights the new advances and better understanding in the pathophysiology of diarrheal diseases and their impact on therapy.

Original languageEnglish (US)
Pages (from-to)687-699
Number of pages13
JournalExpert Review of Anti-Infective Therapy
Volume10
Issue number6
DOIs
StatePublished - Jun 1 2012

Keywords

  • diarrhea
  • ion transport
  • microbial interaction
  • pathophysiology
  • tight junction and therapy

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)
  • Virology
  • Infectious Diseases

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