@article{07c87af8bd9f4633a6abf07b4632e368,
title = "Nevirapine resistance in women and infants after first versus repeated use of single-dose nevirapine for prevention of HIV-1 vertical transmission",
abstract = "Single-dose (SD) nevirapine (NVP) significantly reduces mother-to-child transmission of human immunodeficiency virus (HIV). We analyzed NVP resistance after receipt of SDNVP in 57 previously SD NVP-naive women, in 34 SD NVP-experienced women, and in 17 HIV-infected infants. The proportion of women infected with variants with resistance mutations, the types of mutations detected, and the frequency and level of K103N were similar in the two groups ofwomenat 6 weeks and 6 months post partum. NVP resistance was detected in a similar proportion of infants born to SD NVP-naive versus SD NVP-experienced women. Repeated use of SD NVP to prevent HIV transmission does not appear to influence NVP resistance.",
author = "Flys, {Tamara S.} and McConnell, {Michelle S.} and Flavia Matovu and Church, {Jessica D.} and Danstan Bagenda and Leila Khaki and Paul Bakaki and Thigpen, {Michael C.} and Chineta Eure and Fowler, {Mary Glenn} and Eshleman, {Susan H.}",
note = "Funding Information: Financial support: Supported by (1) the HIV Prevention Trials Network, which is sponsored by the National Institute of Allergy and Infectious Diseases, the National Institute of Child Health and Human Development (NICHD), the National Institute on Drug Abuse, the National Institute of Mental Health, and the Office of AIDS Research of the National Institutes of Health, US Department of Health and Human Services (grants U01-AI-46745, U01-AI-48054, and U01-AI-068613); (2) the International Maternal Pediatric and Adolescent AIDS Clinical Trials Network (grant U01-AI-068633); (3) the NICHD (grant R01-HD042965); and (4) the US Centers for Disease Control and Prevention.",
year = "2008",
month = aug,
day = "15",
doi = "10.1086/590160",
language = "English (US)",
volume = "198",
pages = "465--469",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "4",
}