Neutrophil targeted nano-drug delivery system for chronic obstructive lung diseases

Neeraj Vij, Taehong Min, Manish Bodas, Aakruti Gorde, Indrajit Roy

Research output: Contribution to journalArticle

Abstract

The success of drug delivery to target airway cell(s) remains a significant challenge due to the limited ability of nanoparticle (NP) systems to circumvent protective airway-defense mechanisms. The size, density, surface and physical–chemical properties of nanoparticles are the key features that determine their ability to navigate across the airway-barrier. We evaluated here the efficacy of a PEGylated immuno-conjugated PLGA-nanoparticle (PINP) to overcome this challenge and selectively deliver drug to specific inflammatory cells (neutrophils). We first characterized the size, shape, surface-properties and neutrophil targeting using dynamic laser scattering, transmission electron microscopy and flow cytometry. Next, we assessed the efficacy of neutrophil-targeted PINPs in transporting through the airway followed by specific binding and release of drug to neutrophils. Finally, our results demonstrate the efficacy of PINP mediated non-steroidal anti-inflammatory drug‐(ibuprofen) delivery to neutrophils in murine models of obstructive lung diseases, based on its ability to control neutrophilic-inflammation and resulting lung disease.

Original languageEnglish (US)
Pages (from-to)2415-2427
Number of pages13
JournalNanomedicine: Nanotechnology, Biology, and Medicine
Volume12
Issue number8
DOIs
StatePublished - Nov 1 2016

Keywords

  • COPD
  • Cystic fibrosis
  • Drug delivery
  • Emphysema
  • Lungs
  • Nanoparticle
  • Neutrophils
  • NFκB

ASJC Scopus subject areas

  • Molecular Medicine
  • Bioengineering
  • Biomedical Engineering
  • Materials Science(all)
  • Medicine (miscellaneous)
  • Pharmaceutical Science

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