Neutrophil-rich, Ki-1-positive anaplastic large-cell malignant lymphoma

K. P. Mann, B. Hall, H. Kamino, M. J. Borowitz, H. Ratech

Research output: Contribution to journalArticle

Abstract

The presence of neutrophils, in the absence of necrosis, is uncommon in malignant lymphoma (ML). We identified a subgroup of Ki-1-positive anaplastic large cell ML (Ki-1 ALCL) in which neutrophils were a prominent component. Six of 20 cases of Ki-1 ALCL had a significant neutrophil infiltrate that varied from 5 to 10% to >50% of cells per high power field. Neutrophils were not seen in 100 cases of other types of ML reviewed. Patients were first seen with skin lesions (four), localized lymphadenopathy (three), generalized lymphadenopathy (one), and localized extranodal disease (one). All had primary disease. Two patients had peripheral neutrophilia. Three of six patients had clinical stage IV disease. Four patients are currently in clinical remission; one died of recurrent disease; and one patient with acquired immunodeficiency syndrome (AIDS) died of Pneumocystis carinii pneumonia. Four cases demonstrated a T-cell phenotype, one of which arose in a patient with AIDS. Two had a B-cell phenotype. All cases were positive for CD30 (Ki-1). These observations expand the morphologic spectrum of Ki-1 ALCL to include a neutrophil-rich variant. We conclude that the presence of neutrophils is another morphologic feature shared by some cases of Ki-1 ALCL, lymphomatoid papulosis, and Hodgkin's disease, which suggests a possible pathogenetic link among them.

Original languageEnglish (US)
Pages (from-to)407-416
Number of pages10
JournalAmerican Journal of Surgical Pathology
Volume19
Issue number4
DOIs
StatePublished - Jan 1 1995
Externally publishedYes

Keywords

  • Anaplastic large-cell lymphoma
  • CD30
  • Human immunodeficiency virus
  • Ki-1
  • Neutrophils

ASJC Scopus subject areas

  • Anatomy
  • Surgery
  • Pathology and Forensic Medicine

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