Neutrophil-lymphocyte and platelet-lymphocyte ratio in patients after resection for hepato-pancreatico-biliary malignancies

G. Spolverato, H. Maqsood, Y. Kim, G. A. Margonis, T. Luo, A. Ejaz, T. M. Pawlik

Research output: Contribution to journalArticle

Abstract

Background and Objectives We sought to determine whether Neutrophil-lymphocyte ratio (NLR) or platelet-lymphocyte ratio (PLR) were associated with outcomes of patients undergoing surgery for a hepatopancreatico-biliary (HPB) malignancy. Method Between 2000 and 2013, 452 patients who underwent an HPB procedure for a malignant indication were identified. Clinicopathological characteristics, NLR, and PLR, as well as short- and long-term outcomes were analyzed. High NLR and PLR were classified using a cut-off value of 5 and 190, respectively, based on ROC curve analysis. Results Patients with low versus high NLR and PLR had similar baseline characteristics with regard to performance status and tumor stage (all P>0.05). Elevated PLR (HR=1.40) tends to be association with shorter recurrence-free survival (RFS) (P=0.05), whereas NLR was not a predictor of shorter RFS. Differently, both elevated NLR (HR=1.94) and PLR (HR=1.79) were associated with worse overall survival (OS) (both P

Original languageEnglish (US)
Pages (from-to)868-874
Number of pages7
JournalJournal of Surgical Oncology
Volume111
Issue number7
DOIs
StatePublished - Jun 1 2015

Keywords

  • hepatopancreatico-biliary surgery
  • neutrophil-lymphocyte ratio
  • outcome
  • platelets-lymphocyte ratio

ASJC Scopus subject areas

  • Surgery
  • Oncology
  • Medicine(all)

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