Neutropenia in human immunodeficiency virus infection

Data from the women's interagency HIV study

Alexandra M. Levine, Roksana Karim, Wendy Mack, Jay Gravink, Katherine Anastos, Mary Young, Mardge Cohen, Meg Newman, Michael Augenbraun, Stephen J Gange, D. Heather Watts

Research output: Contribution to journalArticle

Abstract

Background: Neutropenia is well described in individuals infected withhumanimmunodeficiency virus (HIV) and occurs in approximately 10% to 50% of cases. Neither the effect of highly active antiretroviral therapy (HAART) on neutrophil counts nor the significance of neutropenia in terms of survival has previously been evaluated. Methods: The prevalence of neutropenia among 1729 HIV-infected women, followed up as part of the Women's Interagency HIV Study, was evaluated. The CD4 lymphocyte counts, HIV-1 RNA levels, and complete blood cell counts, including absolute neutrophil counts, were obtained at 6-month intervals. Results: Neutropenia was common among HIV-infected women; at baseline, 44% had neutrophil counts less than 2000/μL, whereas 7% had counts less than 1000/ μL. During 7.5 years of follow-up, neutrophil counts less than 2000/μL occurred on at least 1 occasion in 79%, whereas absolute neutrophil counts less than 1000/μL were documented in 31%. Worsening HIV disease parameters, such as lower CD4 cell counts (P

Original languageEnglish (US)
Pages (from-to)405-410
Number of pages6
JournalArchives of Internal Medicine
Volume166
Issue number4
DOIs
StatePublished - Feb 27 2006

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Virus Diseases
Neutropenia
Neutrophils
HIV
Blood Cell Count
CD4 Lymphocyte Count
Highly Active Antiretroviral Therapy
HIV-1
RNA
Viruses
Survival

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Levine, A. M., Karim, R., Mack, W., Gravink, J., Anastos, K., Young, M., ... Watts, D. H. (2006). Neutropenia in human immunodeficiency virus infection: Data from the women's interagency HIV study. Archives of Internal Medicine, 166(4), 405-410. https://doi.org/10.1001/.405

Neutropenia in human immunodeficiency virus infection : Data from the women's interagency HIV study. / Levine, Alexandra M.; Karim, Roksana; Mack, Wendy; Gravink, Jay; Anastos, Katherine; Young, Mary; Cohen, Mardge; Newman, Meg; Augenbraun, Michael; Gange, Stephen J; Watts, D. Heather.

In: Archives of Internal Medicine, Vol. 166, No. 4, 27.02.2006, p. 405-410.

Research output: Contribution to journalArticle

Levine, AM, Karim, R, Mack, W, Gravink, J, Anastos, K, Young, M, Cohen, M, Newman, M, Augenbraun, M, Gange, SJ & Watts, DH 2006, 'Neutropenia in human immunodeficiency virus infection: Data from the women's interagency HIV study', Archives of Internal Medicine, vol. 166, no. 4, pp. 405-410. https://doi.org/10.1001/.405
Levine, Alexandra M. ; Karim, Roksana ; Mack, Wendy ; Gravink, Jay ; Anastos, Katherine ; Young, Mary ; Cohen, Mardge ; Newman, Meg ; Augenbraun, Michael ; Gange, Stephen J ; Watts, D. Heather. / Neutropenia in human immunodeficiency virus infection : Data from the women's interagency HIV study. In: Archives of Internal Medicine. 2006 ; Vol. 166, No. 4. pp. 405-410.
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