Neutropenia in human immunodeficiency virus infection: Data from the women's interagency HIV study

Alexandra M. Levine, Roksana Karim, Wendy Mack, Jay Gravink, Katherine Anastos, Mary Young, Mardge Cohen, Meg Newman, Michael Augenbraun, Stephen J Gange, D. Heather Watts

Research output: Contribution to journalArticle

Abstract

Background: Neutropenia is well described in individuals infected withhumanimmunodeficiency virus (HIV) and occurs in approximately 10% to 50% of cases. Neither the effect of highly active antiretroviral therapy (HAART) on neutrophil counts nor the significance of neutropenia in terms of survival has previously been evaluated. Methods: The prevalence of neutropenia among 1729 HIV-infected women, followed up as part of the Women's Interagency HIV Study, was evaluated. The CD4 lymphocyte counts, HIV-1 RNA levels, and complete blood cell counts, including absolute neutrophil counts, were obtained at 6-month intervals. Results: Neutropenia was common among HIV-infected women; at baseline, 44% had neutrophil counts less than 2000/μL, whereas 7% had counts less than 1000/ μL. During 7.5 years of follow-up, neutrophil counts less than 2000/μL occurred on at least 1 occasion in 79%, whereas absolute neutrophil counts less than 1000/μL were documented in 31%. Worsening HIV disease parameters, such as lower CD4 cell counts (P

Original languageEnglish (US)
Pages (from-to)405-410
Number of pages6
JournalArchives of Internal Medicine
Volume166
Issue number4
DOIs
StatePublished - Feb 27 2006

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Virus Diseases
Neutropenia
Neutrophils
HIV
Blood Cell Count
CD4 Lymphocyte Count
Highly Active Antiretroviral Therapy
HIV-1
RNA
Viruses
Survival

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Levine, A. M., Karim, R., Mack, W., Gravink, J., Anastos, K., Young, M., ... Watts, D. H. (2006). Neutropenia in human immunodeficiency virus infection: Data from the women's interagency HIV study. Archives of Internal Medicine, 166(4), 405-410. https://doi.org/10.1001/.405

Neutropenia in human immunodeficiency virus infection : Data from the women's interagency HIV study. / Levine, Alexandra M.; Karim, Roksana; Mack, Wendy; Gravink, Jay; Anastos, Katherine; Young, Mary; Cohen, Mardge; Newman, Meg; Augenbraun, Michael; Gange, Stephen J; Watts, D. Heather.

In: Archives of Internal Medicine, Vol. 166, No. 4, 27.02.2006, p. 405-410.

Research output: Contribution to journalArticle

Levine, AM, Karim, R, Mack, W, Gravink, J, Anastos, K, Young, M, Cohen, M, Newman, M, Augenbraun, M, Gange, SJ & Watts, DH 2006, 'Neutropenia in human immunodeficiency virus infection: Data from the women's interagency HIV study', Archives of Internal Medicine, vol. 166, no. 4, pp. 405-410. https://doi.org/10.1001/.405
Levine, Alexandra M. ; Karim, Roksana ; Mack, Wendy ; Gravink, Jay ; Anastos, Katherine ; Young, Mary ; Cohen, Mardge ; Newman, Meg ; Augenbraun, Michael ; Gange, Stephen J ; Watts, D. Heather. / Neutropenia in human immunodeficiency virus infection : Data from the women's interagency HIV study. In: Archives of Internal Medicine. 2006 ; Vol. 166, No. 4. pp. 405-410.
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