Neutralization of vascular endothelial growth factor slows progression of retinal nonperfusion in patients with diabetic macular edema

Peter A Campochiaro, Charles C. Wykoff, Howard Shapiro, Roman G. Rubio, Jason S. Ehrlich

Research output: Contribution to journalArticle


Objective To determine the effect of suppression of vascular endothelial growth factor (VEGF) by monthly injection of ranibizumab on posterior retinal nonperfusion (RNP) in patients with diabetic macular edema (DME). Design Unplanned retrospective analysis of prospectively collected data from 2 randomized, sham injection-controlled, double-masked, multicenter clinical trials. Participants Six hundred sixty-six patients with DME. Methods An independent reading center measured the area of RNP on fluorescein angiograms obtained in the phase 3 RISE and RIDE trials. Main Outcome Measures The percentage of patients with no posterior RNP. Results The percentage of patients with no posterior RNP decreased in the sham group between baseline and month 24, but remained relatively stable in the 2 ranibizumab groups. After month 24, the sham group crossed over to receive monthly injections of ranibizumab 0.5 mg, and the differences between the sham and ranibizumab groups were reduced. The percentage of patients who showed an increase in posterior RNP from baseline increased over time in all 3 groups, but at a faster rate in the sham group, resulting in statistically significant differences at every time point between months 3 (9.6% vs. 18.5%; P = 0.016) and 24 (16.1% vs. 37.6%; P

Original languageEnglish (US)
Pages (from-to)1783-1789
Number of pages7
Issue number9
Publication statusPublished - 2014



  • Abbreviations and Acronyms
  • branch retinal vein occlusion
  • BRVO
  • central retinal vein occlusion
  • CRVO
  • DA
  • diabetic macular edema
  • disc area
  • DME
  • Early Treatment Diabetic Retinopathy Study
  • ranibizumab
  • RBZ
  • retinal nonperfusion
  • retinal vein occlusion
  • RNP
  • RVO
  • vascular endothelial growth factor
  • VEGF

ASJC Scopus subject areas

  • Ophthalmology

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