Abstract
Physiological and pathological processes that increase or decrease the central nervoussystem's need for nutrients and oxygen via changes in local blood supply act primarilyat the level of the neurovascular unit (NVU). The NVU consists of endothelial cells,associated blood-brain barrier tight junctions, basal lamina, pericytes, and parenchymalcells, including astrocytes, neurons, and interneurons. Knowledge of the NVU is essentialfor interpretation of central nervous system physiology and pathology as revealed byconventional and advanced imaging techniques. This article reviews current strategies forinterrogating the NVU, focusing on vascular permeability, blood volume, and functionalimaging, as assessed by ferumoxytol an iron oxide nanoparticle.
Original language | English (US) |
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Pages (from-to) | 770-780 |
Number of pages | 11 |
Journal | Neurosurgery |
Volume | 82 |
Issue number | 6 |
DOIs | |
State | Published - Jun 1 2018 |
Keywords
- Blood-brain barrier
- Imaging
- Neurovascular unit
ASJC Scopus subject areas
- Clinical Neurology
- Surgery