Neurotrophin-3 signaling maintains maturational homeostasis between neuronal populations in the olfactory epithelium

P. Jeanette Simpson, Eugene Wang, Cheil Moon, Valéry Matarazzo, Deborah R S Cohen, Daniel J. Liebl, Gabriele V. Ronnett

Research output: Contribution to journalArticle

Abstract

Neurons within the olfactory system undergo functional turnover throughout life. This process of cell death and compensatory neurogenesis requires feedback between neuronal populations of different developmental ages. We examined the role of NT-3 in this process. NT-3 was localized within both the olfactory bulb and olfactory epithelium. Mice null for NT-3 showed increased numbers of immature neurons, without change in the number of mature neurons. This was due to compensatory alterations in apoptosis of mature and immature neuronal populations. Using a primary olfactory neuronal culture, NT-3 was found to directly activate the PI3K/Akt pathway and indirectly activate the MAPK and PLC pathways. Activated PI3K/Akt promoted mature neuronal survival and induced the release of secondary factors, which activated the MAPK and PLC pathways to reduce neuronal precursor proliferation and inhibit neuronal maturation. These effects of NT-3 serve to maintain homeostasis between neuronal populations within the olfactory epithelium.

Original languageEnglish (US)
Pages (from-to)858-874
Number of pages17
JournalMolecular and Cellular Neuroscience
Volume24
Issue number4
DOIs
StatePublished - Dec 2003

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Neurotrophin 3
Olfactory Mucosa
Homeostasis
Phosphatidylinositol 3-Kinases
Neurons
Population
Olfactory Bulb
Neurogenesis
Cell Death
Apoptosis

ASJC Scopus subject areas

  • Molecular Biology
  • Cellular and Molecular Neuroscience
  • Developmental Neuroscience

Cite this

Neurotrophin-3 signaling maintains maturational homeostasis between neuronal populations in the olfactory epithelium. / Simpson, P. Jeanette; Wang, Eugene; Moon, Cheil; Matarazzo, Valéry; Cohen, Deborah R S; Liebl, Daniel J.; Ronnett, Gabriele V.

In: Molecular and Cellular Neuroscience, Vol. 24, No. 4, 12.2003, p. 858-874.

Research output: Contribution to journalArticle

Simpson, P. Jeanette ; Wang, Eugene ; Moon, Cheil ; Matarazzo, Valéry ; Cohen, Deborah R S ; Liebl, Daniel J. ; Ronnett, Gabriele V. / Neurotrophin-3 signaling maintains maturational homeostasis between neuronal populations in the olfactory epithelium. In: Molecular and Cellular Neuroscience. 2003 ; Vol. 24, No. 4. pp. 858-874.
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