Abstract
Because neurotrophic factors can prevent natural and experirmental cases of neural cell death and induce and maintain differentiation, they are especially attractive agents for the treatment of neurodegnerative diseases, such as Alzheimer's disease (AD). The present report argues for the specific role of particular families of trophic factors, such as neurotrophins (e.g., nerve growth factor [NGF]) and neurokines (e.g., ciliary neurotrophic factor [CNTF]), for the promotion of the survival and phenotype of subsets of central nervous system (CNS) neurons vulnerable in AD, such as basal forebrain cholinergic neurons and cortical projection neurons. Although there is ample evidence for the therapeutic role of NGF in experimental or natural injury of cholinergic neurons, not enough progress has been made on trophic models involving cortical neurons. Further understanding of the mechanisms of cell death in AD and elucidation of the transduction cascades of trophic factors will undoubtedly refine our current concepts of a neurotrophic treatment for AD.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 292-299 |
| Number of pages | 8 |
| Journal | Annals of the New York Academy of Sciences |
| Volume | 695 |
| DOIs | |
| State | Published - 1993 |
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ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
Neurotrophic strategies for treating Alzheimer's disease : Lessons from basic neurobiology and animal models. / Koliatsos, Vassilis El; Price, D. L.; Clatterbuck, R. E.; Markowska, A. L.; Olton, D. S.; Wilcox, B. J.
In: Annals of the New York Academy of Sciences, Vol. 695, 1993, p. 292-299.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Neurotrophic strategies for treating Alzheimer's disease
T2 - Lessons from basic neurobiology and animal models
AU - Koliatsos, Vassilis El
AU - Price, D. L.
AU - Clatterbuck, R. E.
AU - Markowska, A. L.
AU - Olton, D. S.
AU - Wilcox, B. J.
PY - 1993
Y1 - 1993
N2 - Because neurotrophic factors can prevent natural and experirmental cases of neural cell death and induce and maintain differentiation, they are especially attractive agents for the treatment of neurodegnerative diseases, such as Alzheimer's disease (AD). The present report argues for the specific role of particular families of trophic factors, such as neurotrophins (e.g., nerve growth factor [NGF]) and neurokines (e.g., ciliary neurotrophic factor [CNTF]), for the promotion of the survival and phenotype of subsets of central nervous system (CNS) neurons vulnerable in AD, such as basal forebrain cholinergic neurons and cortical projection neurons. Although there is ample evidence for the therapeutic role of NGF in experimental or natural injury of cholinergic neurons, not enough progress has been made on trophic models involving cortical neurons. Further understanding of the mechanisms of cell death in AD and elucidation of the transduction cascades of trophic factors will undoubtedly refine our current concepts of a neurotrophic treatment for AD.
AB - Because neurotrophic factors can prevent natural and experirmental cases of neural cell death and induce and maintain differentiation, they are especially attractive agents for the treatment of neurodegnerative diseases, such as Alzheimer's disease (AD). The present report argues for the specific role of particular families of trophic factors, such as neurotrophins (e.g., nerve growth factor [NGF]) and neurokines (e.g., ciliary neurotrophic factor [CNTF]), for the promotion of the survival and phenotype of subsets of central nervous system (CNS) neurons vulnerable in AD, such as basal forebrain cholinergic neurons and cortical projection neurons. Although there is ample evidence for the therapeutic role of NGF in experimental or natural injury of cholinergic neurons, not enough progress has been made on trophic models involving cortical neurons. Further understanding of the mechanisms of cell death in AD and elucidation of the transduction cascades of trophic factors will undoubtedly refine our current concepts of a neurotrophic treatment for AD.
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UR - http://www.scopus.com/inward/citedby.url?scp=0027375807&partnerID=8YFLogxK
U2 - 10.1111/j.1749-6632.1993.tb23069.x
DO - 10.1111/j.1749-6632.1993.tb23069.x
M3 - Article
C2 - 8239298
AN - SCOPUS:0027375807
VL - 695
SP - 292
EP - 299
JO - Annals of the New York Academy of Sciences
JF - Annals of the New York Academy of Sciences
SN - 0077-8923
ER -