Neurotrophic factors in autonomic nervous system plasticity and dysfunction

Mark P. Mattson, Ruiqian Wan

Research output: Contribution to journalArticle

Abstract

During development, neurotrophic factors are known to play important roles in regulating the survival of neurons in the autonomic nervous system (ANS) and the formation of their synaptic connectivity with their peripheral targets in the cardiovascular, digestive, and other organ systems. Emerging findings suggest that neurotrophic factors may also affect the functionality of the ANS during adult life and may, in part, mediate the effects of environmental factors such as exercise and dietary energy intake on ANS neurons and target cells. In this article, we describe the evidence that ANS neurons express receptors for multiple neurotrophic factors, and data suggesting that activation of those receptors can modify plasticity in the ANS. Neurotrophic factors that may regulate ANS function include brain-derived neurotrophic factor, nerve growth factor, insulin-like growth factors, and ciliary neurotrophic factor. The possibility that perturbed neurotrophic factor signaling is involved in the pathogenesis of ANS dysfunction in some neurological disorders is considered, together with implications for neurotrophic factor-based therapeutic interventions.

Original languageEnglish (US)
Pages (from-to)157-168
Number of pages12
JournalNeuroMolecular Medicine
Volume10
Issue number3
DOIs
StatePublished - Sep 2008
Externally publishedYes

Fingerprint

Autonomic Nervous System
Nerve Growth Factors
Neurons
Ciliary Neurotrophic Factor
Nerve Growth Factor Receptors
Brain-Derived Neurotrophic Factor
Nerve Growth Factor
Somatomedins
Energy Intake
Nervous System Diseases

Keywords

  • Alzheimer's disease
  • BDNF
  • CNTF
  • NGF
  • Parasympathetic
  • Parkinson's disease
  • Sympathetic

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Molecular Medicine
  • Neurology

Cite this

Neurotrophic factors in autonomic nervous system plasticity and dysfunction. / Mattson, Mark P.; Wan, Ruiqian.

In: NeuroMolecular Medicine, Vol. 10, No. 3, 09.2008, p. 157-168.

Research output: Contribution to journalArticle

Mattson, Mark P. ; Wan, Ruiqian. / Neurotrophic factors in autonomic nervous system plasticity and dysfunction. In: NeuroMolecular Medicine. 2008 ; Vol. 10, No. 3. pp. 157-168.
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